Antagonists & inhibitors
An antagonist is a drug or chemical that reduces the effect of an agonist. Competitive antagonists bind to the same site on a receptor as the agonist but do not activate it - thereby blocking the action of the agonist. Non-competitive antagonists block the action of the agonist by binding to a different site on the receptor (an allosteric or non-agonist site). A reversible antagonist binds non-covalently and can be washed out. An irreversible antagonist binds covalently and cannot be displaced by either competing ligands or washing. Inhibitors are drugs that can bind to a protein, such as an enzyme and decrease its activity. Researchers can save up to 50% on competitive antagonists, non-competitive antagonists, reversible and irreversible antagonists, and inhibitors from Hello Bio - they are up to half the price of other suppliers.
Anti-GST tag antibody ValidAbTM (HB9897)
Description:Antibody to the GST tag - widely used as a protein tag in molecular biology. Part of the ValidAbâ„¢ range of highly validated, data-rich antibodies.Â
Host: MouseClonality: MonoclonalReactivity Tested: Species IndependentAnti-Histone H3 antibody ValidAbâ„¢ (HB6980)
Description:Antibody to Histone H3 - Histone protein used as a loading control for western blotting. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: RabbitClonality: PolyclonalReactivity Tested: Mouse, RatAnti-HSP60 antibody ValidAbâ„¢ (HB7863)
Description:Antibody to HSP60 - loading control and mitochondrial marker for immunohistochemistry and immunocytochemistry. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: MouseClonality: MonoclonalReactivity Tested: Mouse, Rat, Human10Z-Hymenialdisine (HB1264)
Description:Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
Purity:>97%
Anti-IBA1 antibody ValidAbTM (HB7847)
Description:Antibody to IBA1 - calcium binding protein widely used as a marker for microglial cells. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: RabbitClonality: PolyclonalReactivity Tested: Mouse, RatI-BET 151 hydrochloride (HB1446)
Description:BET bromodomain inhibitor, also promotes differentiation of hiPSCs into megakaryocytes
Purity:>98%
Jasplakinolide (HB3946)
Description:Cell permeable, non-fluorescent F-actin probe. Induces actin polymerization and stabilization.
Purity:>98%
(+)-JQ1 (HB1448)
Description:Potent, selective BET bromodomain inhibitor. Cell permeable.
Purity:>98%
Anti-Ki-67 antibody ValidAbTM (HB7052)
Description:Antibody to Ki-67 - a widely used marker of proliferating cells. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: MouseClonality: MonoclonalReactivity Tested: Human