DREADD

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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).

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  2. Clozapine (HB1607)

    1  Review
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    Description:

    Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors

    Purity:

    >99%

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    €18
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  3. Pack:
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    Pack:
    5mg (10mM in water)
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  4. 3  Reviews
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    Description:

    Water soluble prototypic, atypical antipsychotic. Binds to both serotonin and dopamine receptors.

    Purity:

    >98%

    Pack:
    5mg
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    €30
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    €43
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    €180
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  5. 19  Reviews
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    Description:

    Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant. Water soluble.

    Purity:

    >98%

    Pack:
    1mg
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    €30
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    100mg
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    €890
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  6. Description:

    Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant.

    Purity:

    >98%

    Pack:
    5mg
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    €103
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    €154
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    €326
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    €532
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    100mg
    Price:
    €1,020
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  7. Description:

    Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator.

    Purity:

    >98%

    Pack:
    5mg
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    €80
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  8. 5  Reviews
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    Description:

    Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator. Water soluble.

    Purity:

    >99%

    Pack:
    5mg
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    €85
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    10mg
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    €139
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    25mg
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    €210
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    50mg
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    €343
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    100mg
    Price:
    €622
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  9. Description:

    Novel DREADD agonist with high affinity and potency for hM3Dq and hM4Di. Active in vivo. Freebase.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    €83
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    10mg
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    €160
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    25mg
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    €332
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    100mg
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    €954
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  10. Description:

    Novel DREADD agonist with high affinity and potency for hM3Dq and hM4Di. Active in vivo. Water soluble.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    €100
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    10mg
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    €193
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    25mg
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    €401
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    100mg
    Price:
    €1,400
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