Product overview

Name 10Z-Hymenialdisine
Description Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
Alternative names SK&F 108752
Purity >97%
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Biological Data

Biological description Pan kinase inhibitor. Potently inhibits MEK1 (IC50 = 6 nM at MEK-1) and GSK-3β. Also Inhibits IL-8, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDk3/cyclin E and CDK5/p35 (IC50 values are 0.41 µM, 22, 70, 40, 100 and 28 nM respectively). Exhibits reduced activity at CDK4/cyclin D1 and CDK6/cyclin D2 (IC50 values are 600 and 700 nM respectively). Displays growth inhibitory properties towards tumor cells.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4 H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropy rrolo[2,3-c]azepin-8(1H)-one
Molecular Weight 324.13
Chemical structure 10Z-Hymenialdisine  [82005-12-7] Chemical Structure
Molecular Formula C11H10BrN5O2
CAS Number 82005-12-7
PubChem identifier 3035462
SMILES O=C(NCC1)C2=C(C=C(Br)N2)/C1=C3/C(N=C(N)N3)=O
InChiKey ATBAETXFFCOZOY-DAXSKMNVSA-N

References for 10Z-Hymenialdisine

References are publications that support the biological activity of the product
  • Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

    Tasdemir D et al (2002) J Med Chem 45(2) : 529-32.
  • Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

    Meijer L et al (2000) Chem Biol 7(1) : 51-63.