Pan kinase inhibitor. Potently inhibits MEK1 (IC50 = 6 nM at MEK-1) and GSK-3β. Also Inhibits IL-8, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDk3/cyclin E and CDK5/p35 (IC50 values are 0.41 µM, 22, 70, 40, 100 and 28 nM respectively). Exhibits reduced activity at CDK4/cyclin D1 and CDK6/cyclin D2 (IC50 values are 600 and 700 nM respectively). Displays growth inhibitory properties towards tumor cells.
Solubility & Handling
Solubility overview
Soluble in DMSO (10mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![10Z-Hymenialdisine [82005-12-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1264.png "10Z-Hymenialdisine [82005-12-7]")
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