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10Z-Hymenialdisine

(HB1264)
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Product overview

Name 10Z-Hymenialdisine
Alternative names SK&F 108752
Purity >97%
Description Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2)
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Biological Data

Biological description Pan kinase inhibitor. Potently inhibits MEK1 (IC50 = 6 nM at MEK-1) and GSK-3β. Also Inhibits IL-8, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDk3/cyclin E and CDK5/p35 (IC50 values are 0.41 µM, 22, 70, 40, 100 and 28 nM respectively). Exhibits reduced activity at CDK4/cyclin D1 and CDK6/cyclin D2 (IC50 values are 600 and 700 nM respectively). Displays growth inhibitory properties towards tumor cells.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >97%
Chemical name (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4 H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropy rrolo[2,3-c]azepin-8(1H)-one
Molecular Weight 324.13
Chemical structure 10Z-Hymenialdisine [82005-12-7] Chemical Structure
Molecular Formula C11H10BrN5O2
CAS Number 82005-12-7
PubChem identifier 3035462
SMILES O=C(NCC1)C2=C(C=C(Br)N2)/C1=C3/C(N=C(N)N3)=O
InChiKey ATBAETXFFCOZOY-DAXSKMNVSA-N

References for 10Z-Hymenialdisine

References are publications that support the biological activity of the product

  • Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

    Tasdemir D et al (2002) J Med Chem 45(2) : 529-32.
    Read more (PubMedID: 11784156)

  • Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent.

    Meijer L et al (2000) Chem Biol 7(1) : 51-63.
    Read more (PubMedID: 10662688)

2 Item(s)

Grouped product items
Order: HB1264
Pack PriceQty
250μg
$201
1mg
$669
Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
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