Pan kinase inhibitor. Potently inhibits MEK1 (IC50 = 6 nM at MEK-1) and GSK-3β. Also Inhibits IL-8, CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDk3/cyclin E and CDK5/p35 (IC50 values are 0.41 µM, 22, 70, 40, 100 and 28 nM respectively). Exhibits reduced activity at CDK4/cyclin D1 and CDK6/cyclin D2 (IC50 values are 600 and 700 nM respectively). Displays growth inhibitory properties towards tumor cells.
Solubility & Handling
Soluble in DMSO (10mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.