Organoids

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Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.

Items 1-10 of 13

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  1. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $48
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5×2mg
    Price:
    $180
    Qty:
    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    5mg
    Price:
    $112
    Qty:
    Pack:
    25mg
    Price:
    $427
    Qty:
    Pack:
    50mg
    Price:
    $727
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $121
    Qty:
  2. Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $220
    Qty:
    Pack:
    50mg
    Price:
    $879
    Qty:
  3. DAPT (HB3345)

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    Description:

    γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $168
    Qty:
    Pack:
    25mg
    Price:
    $418
    Qty:
    Pack:
    50mg
    Price:
    $703
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $109
    Qty:
  4. Forskolin (HB1348)

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    Description:

    Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $124
    Free trial
    Qty:
    Pack:
    50mg
    Price:
    $523
    Qty:
  5. Pack:
    250μg
    Price:
    $99
    Qty:
    Pack:
    1mg
    Price:
    $265
    Qty:
  6. IWP 2 (HB0344)

    Description:

    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $359
    Qty:
  7. IWP 4 (HB3066)

    Description:

    Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $534
    Qty:
  8. Description:

    Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $176
    Qty:
    Pack:
    50mg
    Price:
    $635
    Qty:
  9. PD 0325901 (HB2240)

    Description:

    Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    Qty:
    Pack:
    2mg
    Price:
    $28
    Qty:
    Pack:
    5×2mg
    Price:
    $115
    Qty:
    Pack:
    10mg
    Price:
    $109
    Qty:
    Pack:
    50mg
    Price:
    $308
    Qty:
  10. Description:

    Endogenous prostanoid. Induces hematopoietic stem cell proliferation. 3D growth matrix component and used in production of liver and prostate organoids.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $160
    Qty:
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