Organoids

Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules (e.g. Rocki Y-27632, CHIR and SB431542) are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.

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Items 1-10 of 14

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  1. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    €48
    Qty:
    Pack:
    2mg
    Price:
    €57
    Free trial
    Qty:
    Pack:
    5×2mg
    Price:
    €178
    Qty:
    Pack:
    10mg
    Price:
    €174
    Qty:
    Pack:
    5mg
    Price:
    €110
    Qty:
    Pack:
    25mg
    Price:
    €431
    Qty:
    Pack:
    50mg
    Price:
    €689
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    €119
    Qty:
  2. Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    €223
    Qty:
    Pack:
    50mg
    Price:
    €897
    Qty:
  3. DAPT (HB3345)

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    Description:

    γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    €95
    Free trial
    Qty:
    Pack:
    10mg
    Price:
    €160
    Qty:
    Pack:
    25mg
    Price:
    €381
    Qty:
    Pack:
    50mg
    Price:
    €644
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    €106
    Qty:
  4. Forskolin (HB1348)

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    Description:

    Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    €124
    Free trial
    Qty:
    Pack:
    50mg
    Price:
    €487
    Qty:
  5. Pack:
    250μg
    Price:
    €133
    Free trial
    Qty:
    Pack:
    1mg
    Price:
    €253
    Qty:
  6. IWP 2 (HB0344)

    Description:

    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    €359
    Qty:
  7. IWP 4 (HB3066)

    Description:

    Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    €532
    Qty:
  8. Description:

    Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    €176
    Qty:
    Pack:
    50mg
    Price:
    €638
    Qty:
  9. PD 0325901 (HB2240)

    Description:

    Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    €21
    Free trial
    Qty:
    Pack:
    2mg
    Price:
    €28
    Qty:
    Pack:
    5×2mg
    Price:
    €90
    Qty:
    Pack:
    10mg
    Price:
    €83
    Qty:
    Pack:
    50mg
    Price:
    €297
    Qty:
  10. Description:

    Endogenous prostanoid. Induces hematopoietic stem cell proliferation. 3D growth matrix component and used in production of liver and prostate organoids.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    €95
    Qty:
    Pack:
    10mg
    Price:
    €155
    Qty:
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