Organoids

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Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.

Items 1-10 of 13

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  1. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $44
    Qty:
    Pack:
    5mg
    Price:
    $102
    Qty:
    Pack:
    10mg
    Price:
    $159
    Qty:
    Pack:
    25mg
    Price:
    $388
    Qty:
    Pack:
    50mg
    Price:
    $661
    Qty:
  2. Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $200
    Qty:
    Pack:
    50mg
    Price:
    $799
    Qty:
  3. DAPT (HB3345)

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    Description:

    γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $90
    Qty:
    Pack:
    10mg
    Price:
    $153
    Qty:
    Pack:
    25mg
    Price:
    $380
    Qty:
    Pack:
    50mg
    Price:
    $639
    Qty:
    Pack:
    2x5mg
    Price:
    $170
    Qty:
    Pack:
    2x25mg
    Price:
    $680
    Qty:
  4. Forskolin (HB1348)

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    Description:

    Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $113
    Qty:
    Pack:
    50mg
    Price:
    $475
    Qty:
  5. Description:

    Selective CCK2 agonist. Endogenous peptide.

    Pack:
    250μg
    Price:
    $90
    Qty:
    Pack:
    1mg
    Price:
    $241
    Qty:
  6. IWP 2 (HB0344)

    Description:

    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $326
    Qty:
  7. IWP 4 (HB3066)

    Description:

    Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $485
    Qty:
  8. Description:

    Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $160
    Qty:
    Pack:
    50mg
    Price:
    $577
    Qty:
  9. PD 0325901 (HB2240)

    Description:

    Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $99
    Qty:
    Pack:
    50mg
    Price:
    $280
    Qty:
  10. Description:

    Endogenous prostanoid. Induces hematopoietic stem cell proliferation. 3D growth matrix component and used in production of liver and prostate organoids.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $145
    Qty:

Items 1-10 of 13

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