Virus replication, transcription & maturation

Following viral binding and entry, SARS-CoV-2 releases genomic RNA into the host cell which is translated into the pp1a and pp1ab polyproteins. PLpro and Mpro proteases then cleave these polyproteins to produce non-structural proteins such as the RNA Polymerases RdRp and helicase, which are involved in the transcription and replication of the virus. Viral proteins and genome RNA are assembled into virions in the ER and Golgi and then transported via vesicles and released out of the cell. Researchers can save up to 50% on small molecules that affect virus replication, transcription & maturation, as they are up to half the price of other suppliers.

Small molecule inhibitors and modulators of RdRP, viral proteases and the endosomal pathway are being investigated as part of ongoing COVID-19 research. View products: RNA Polymerases (RdRP/ RNAP) | Endocytosis / Endosome | Viral proteases

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Items 1-10 of 16

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  1. Actinomycin D (HB1477)

    9  Reviews
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    Description:

    RNA polymerase inhibitor. Apoptosis inducer.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $124
    Qty:
    Pack:
    5mg
    Price:
    $67
    Qty:
    Pack:
    100mg
    Price:
    $884
    Qty:
    Pack:
    25mg
    Price:
    $232
    Qty:
  2. Bafilomycin A1 (HB1125)

    2  Reviews
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    100% of 100
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    Description:

    Highly potent, selective V-ATPase inhibitor. Autophagy inhibitor.

    Purity:

    >98%

    Pack:
    10μg
    Price:
    $110
    Qty:
    Pack:
    100μg
    Price:
    $303
    Qty:
  3. Pack:
    1g
    Price:
    $33
    Qty:
    Pack:
    5g
    Price:
    $97
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    Pack:
    10g
    Price:
    $174
    Qty:
  4. Pack:
    100mg
    Price:
    $33
    Qty:
    Pack:
    1g
    Price:
    $90
    Qty:
  5. Pack:
    10mg
    Price:
    $116
    Qty:
    Pack:
    50mg
    Price:
    $424
    Qty:
  6. Pack:
    25mg
    Price:
    $169
    Qty:
    Pack:
    100mg
    Price:
    $502
    Qty:
  7. Description:

    α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.

    Purity:

    >95%

    Pack:
    100mg
    Price:
    $54
    Qty:
  8. Pack:
    10mg
    Price:
    $25
    Qty:
    Pack:
    50mg
    Price:
    $58
    Qty:
    Pack:
    250mg
    Price:
    $197
    Qty:
  9. Pack:
    500mg
    Price:
    $40
    Qty:
    Pack:
    1g
    Price:
    $76
    Qty:
  10. Pack:
    100mg
    Price:
    $96
    Qty:
    Pack:
    500mg
    Price:
    $386
    Qty:
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