(+)-JQ1 (JQ1) is a potent, selective and cell permeable inhibitor of the BET (Bromodomain and Extra-Terminal domain) protein family.
JQ1 selectively binds the BRD2, BRD3, BRD4 and BRDT bromodomain proteins (IC50 values are 17.7, 76.9 and 32.6 nM at BRD2, BRD4(N) and BRD4(C) respectively).
JQ1 shows highest affinity for BRD4. JQ1 displaces BRD4 from chromatin by competitively binding to the acetyl-lysine recognition pocket to inhibit transcription.
JQ1 shows effects on tumour growth and survival, cell cycle arrest and differentiation. It has antitumor and anti-angiogenic properties.
JQ1 shows a short half-life of one hour.
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Solubility & Handling
Solubility overview
Soluble in DMSO (100mM) and in ethanol (100mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
![(+)-JQ1 [1268524-70-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1448.png "(+)-JQ1 [1268524-70-4]")
Understanding purity and quality - a guide for life scientists
