Product overview

Name I-BET 151 hydrochloride
Alternative names I-BET151, GSK1210151A
Purity >98%
Description BET bromodomain inhibitor, also promotes differentiation of hiPSCs into megakaryocytes
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Biological Data

Biological description BET bromodomain inhibitor. Inhibits cytokine-induced transcription of STAT targets and downregulates cytokine production. Shows anti-inflammatory and anti-cancer actions. Promotes differentiation of hiPSCs into megakaryocytes.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one hydrochloride
Molecular Weight 451.9
Chemical structure I-BET 151 hydrochloride Chemical Structure
Molecular Formula C23H21N5O3.HCl
CAS Number 1883545-47-8
PubChem identifier 170320

References for I-BET 151 hydrochloride

References are publications that support the biological activity of the product
  • BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes.

    Chan CH et al (2015) Eur J Immunol 45(1) : 287-97.
  • The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers.

    Long J et al (2014) J Biol Chem 289(51) : 35494-502.
  • Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151.

    Gallagher SJ et al (2014) Pigment Cell Melanoma Res 27(6) : 1126-37.

3 Item(s)