TGF-Beta/ SMAD

Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.

TGF-βRI and CK1 inhibitor

TGF-β signaling inhibitor

Selective ALK2 inhibitor. Promotes iPSC neurogenesis.

Selective TGF-β signaling inhibitor. Induces cardiomyocyte differentiation in ESCs.

Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.

Potent, selective TGF-βRI inhibitor. Enhances cellular reprogramming efficiency.

Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.