DREADDs

Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).

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  1. Clozapine (HB1607)

    1  Review
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    Description:

    Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $20
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    10mg
    Price:
    $28
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    25mg
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    $55
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    50mg
    Price:
    $88
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    100mg
    Price:
    $132
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    Pack:
    500mg
    Price:
    $476
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  2. 3  Reviews
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    Description:

    Water soluble prototypic, atypical antipsychotic. Binds to both serotonin and dopamine receptors.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $33
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    10mg
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    $53
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    25mg
    Price:
    $99
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    50mg
    Price:
    $141
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    100mg
    Price:
    $198
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  3. Pack:
    5mg
    Price:
    $96
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    10mg
    Price:
    $138
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    25mg
    Price:
    $310
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    50mg
    Price:
    $573
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    100mg
    Price:
    $934
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    Pack:
    5mg (10mM in water)
    Price:
    $107
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  4. Pack:
    5mg
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    $73
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    10mg
    Price:
    $108
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    25mg
    Price:
    $261
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    50mg
    Price:
    $447
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    100mg
    Price:
    $847
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  5. 2  Reviews
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    Description:

    Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $58
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    Pack:
    10mg
    Price:
    $90
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    Pack:
    25mg
    Price:
    $195
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    Pack:
    50mg
    Price:
    $316
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    Pack:
    100mg
    Price:
    $495
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  6. 15  Reviews
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    Description:

    Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator. Water soluble.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $63
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    Pack:
    10mg
    Price:
    $108
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    Pack:
    25mg
    Price:
    $216
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    Pack:
    50mg
    Price:
    $351
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    Pack:
    100mg
    Price:
    $522
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  7. 27  Reviews
    Top Reviews:
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    Description:

    Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant. Water soluble.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $33
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    Pack:
    5mg
    Price:
    $88
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    Pack:
    10mg
    Price:
    $157
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    25mg
    Price:
    $361
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    Pack:
    50mg
    Price:
    $583
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    Pack:
    100mg
    Price:
    $1,045
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  8. 1  Review
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    Description:

    Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $114
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    Pack:
    10mg
    Price:
    $172
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    Pack:
    25mg
    Price:
    $366
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    Pack:
    50mg
    Price:
    $650
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    Pack:
    100mg
    Price:
    $1,174
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  9. Iperoxo (HB9785)

    Description:

    Potent muscarinic acetylcholine receptor superagonist. Also binds the hM3R-miniGq DREADD receptor.

    Pack:
    1mg
    Price:
    $46
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    10mg
    Price:
    $155
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    Pack:
    50mg
    Price:
    $614
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  10. Description:

    Novel DREADD agonist with high affinity and potency for hM3Dq and hM4Di. Active in vivo. Freebase.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $102
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    Pack:
    10mg
    Price:
    $199
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    Pack:
    25mg
    Price:
    $420
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    Pack:
    100mg
    Price:
    $1,099
    Qty:
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