Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Pack:
    10mg
    Price:
    $209
    Qty:
    Pack:
    50mg
    Price:
    $841
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  2. A83-01 (HB3218)

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    Description:

    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $92
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    Pack:
    25mg
    Price:
    $310
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  3. 17-AAG (HB3599)

    Description:

    Selective Hsp90 inhibitor. Also protects neuroprogenitor cells against apoptosis.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $135
    Qty:
  4. Description:

    Phytohormone and endogenous lanthionine synthetase C-like 2 (LANCL2) ligand

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $143
    Free trial
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    Pack:
    50mg
    Price:
    $626
    Qty:
  5. AICAR (HB2152)

    Description:

    AMPK activator. Promotes osteogenic differentiation of bone marrow-derived MSCs.

    Purity:

    >99%

    Pack:
    25mg
    Price:
    $83
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  6. Pack:
    10mg
    Price:
    $167
    Qty:
  7. L-Ascorbic acid (HB1238)

    Description:

    Antioxidant. Enhances iPSC generation and increases reprogramming efficiency. Supports mesenchymal stem cell proliferation.

    Purity:

    >99%

    Pack:
    100mg
    Price:
    $89
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    Pack:
    1g
    Price:
    $29
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    Pack:
    25g
    Price:
    $43
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    Pack:
    100g
    Price:
    $103
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  8. 5-Azacytidine (HB1374)

    Description:

    DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.

    Purity:

    >98%

    Pack:
    50mg
    Price:
    $70
    Qty:
    Pack:
    250mg
    Price:
    $97
    Qty:
  9. Description:

    L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $130
    Qty:
    Pack:
    50mg
    Price:
    $539
    Qty:
  10. Description:

    Member of the neurotrophin growth factor family. Plays an important role in synaptic plasticity and neurogenesis.

    Pack:
    2μg
    Price:
    $68
    Qty:
    Pack:
    10μg
    Price:
    $271
    Qty:
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