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5-Azacytidine

(HB1374)
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Product overview

Name 5-Azacytidine
Alternative names 5-AzadCyD; NSC 102816; azaCyd; 5-AZC
Purity >98%
Description DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description DNA methyltransferase inhibitor. Causes hypomethylation. Inhibits Wnt-β-catenin signaling pathway and improves stem cell reprogramming efficiency and induces differentiation of Mesenchymal Stem cells (MSCs) into cardiomyocytes. Shows anti-viral, anti-proliferative and anti-cancer actions.

Solubility & Handling

Solubility overview Soluble in water (50mM) or DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-Amino-1-β-D-ribofuranosyl-1,3,5-tr iazin-2(1H)-one
Molecular Weight 244.2
Chemical structure 5-Azacytidine [320-67-2] Chemical Structure
Molecular Formula C8H12N4O5
CAS Number 320-67-2
PubChem identifier 9444
SMILES O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O
InChiKey NMUSYJAQQFHJEW-KVTDHHQDSA-N

References for 5-Azacytidine

References are publications that support the biological activity of the product

  • 5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway.

    Zhang H et al (2014) Genet Mol Res 13(3) : 5064-72.
    Read more (PubMedID: 25061731)

  • 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

    Borodovsky A et al (2013) Oncotarget 4(10) : 1737-47.
    Read more (PubMedID: 24077805)

  • 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

    Dapp MJ et al (2009) J Virol 83(22) : 11950-8.
    Read more (PubMedID: 19726509)

3 Item(s)

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Order: HB1374
Pack PriceQty
50mg
$70
250mg
$97
DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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