Product overview

Name 5-Azacytidine
Description DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
Alternative names 5-AzadCyD; NSC 102816; azaCyd; 5-AZC
Purity >98%
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Biological Data

Biological description DNA methyltransferase inhibitor. Causes hypomethylation. Inhibits Wnt-β-catenin signaling pathway and improves stem cell reprogramming efficiency and induces differentiation of Mesenchymal Stem cells (MSCs) into cardiomyocytes. Shows anti-viral, anti-proliferative and anti-cancer actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (50mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 4-Amino-1-β-D-ribofuranosyl-1,3,5-tr iazin-2(1H)-one
Molecular Weight 244.2
Chemical structure 5-Azacytidine  [320-67-2] Chemical Structure
Molecular Formula C8H12N4O5
CAS Number 320-67-2
PubChem identifier 9444
SMILES O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O
InChiKey NMUSYJAQQFHJEW-KVTDHHQDSA-N

References for 5-Azacytidine

References are publications that support the biological activity of the product
  • 5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway.

    Zhang H et al (2014) Genet Mol Res 13(3) : 5064-72.
  • 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

    Borodovsky A et al (2013) Oncotarget 4(10) : 1737-47.
  • 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

    Dapp MJ et al (2009) J Virol 83(22) : 11950-8.