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Biological Data Biological description DNA methyltransferase inhibitor. Causes hypomethylation. Inhibits Wnt-β-catenin signaling pathway and improves stem cell reprogramming efficiency and induces differentiation of Mesenchymal Stem cells (MSCs) into cardiomyocytes. Shows anti-viral, anti-proliferative and anti-cancer actions.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in water (50mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-Amino-1-β-D-ribofuranosyl-1,3,5-tr iazin-2(1H )-one
Chemical structure
Molecular Formula C8 H12 N4 O5
SMILES O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O
InChiKey NMUSYJAQQFHJEW-KVTDHHQDSA-N
References for 5-Azacytidine References are publications that support the biological activity of the product
5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway. Zhang H et al (2014) Genet Mol Res 13(3) : 5064-72. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Borodovsky A et al (2013) Oncotarget 4(10) : 1737-47. 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1. Dapp MJ et al (2009) J Virol 83(22) : 11950-8.
DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.
![5-Azacytidine [320-67-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1374.png "5-Azacytidine [320-67-2]")
Understanding purity and quality - a guide for life scientists
