Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  2. Description:

    Histone methyltransferase inhibitor. Enhances Oct4 expression in chemically-induced pluripotent stem cells.

    Purity:

    >98%

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    500μg
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  3. Dexamethasone (HB2521)

    Description:

    Anti-inflammatory synthetic glucocorticoid. Induces hMSC differentiation. Apoptosis inducer.

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    >98%

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    100mg
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    $68
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    Description:

    Synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Water soluble and suitable for cell culture. 

    Purity:

    >98%

    Pack:
    100mg
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    $109
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    10mg
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    $217
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    Description:

    Widely used solvent. Improves direct differentiation of pluripotent stem cells and used as a stem cell cryoprotectant

    Purity:

    >99.9%

    Pack:
    10mL
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    $38
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    50mL
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    $119
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    $128
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  7. Description:

    Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.

    Purity:

    >98%

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    10mg
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    $209
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    50mg
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    $829
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  8. 1-EBIO (HB1045)

    Description:

    Epithelial KCa channel activator. Promotes ESC differentiation into cardiomyocytes.

    Purity:

    >98%

    Pack:
    10mg
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    $53
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    50mg
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    $174
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  9. Pack:
    5mg
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    25mg
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  10. Description:

    Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.

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    >98%

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    10mg
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    $111
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