Product overview

Name L-Ascorbic acid
Description Antioxidant. Enhances iPSC generation and increases reprogramming efficiency. Supports mesenchymal stem cell proliferation.
Alternative names L-Ascorbate
Purity >99%
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Biological Data

Biological description

Naturally occurring antioxidant.

Enhances iPSC generation and increases reprogramming efficiency. Also supports mesenchymal stem cell proliferation and promotes differentiation of osteoblasts from human / mouse MSCs and mESCs.


Also a Cav3.2 channel inhibitor (IC50 = 6.5 µM) which exhibits little or no activity at Cav3.1 and Cav3.3 channels.

Commonly used with dexamethasone and β-Gly for osteogenic differentiation of stem cells.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (500mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 3-Oxo-L-gulofuranolactone
Molecular Weight 176.12
Chemical structure L-Ascorbic acid  [50-81-7] Chemical Structure
Molecular Formula C6H8O6
CAS Number 50-81-7
PubChem identifier 54670067
SMILES C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
InChi InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChiKey CIWBSHSKHKDKBQ-JLAZNSOCSA-N
MDL number MFCD00064328

References for L-Ascorbic acid

References are publications that support the biological activity of the product
  • Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.

    Nelson MT et al (2007) J Neurosci 27(46) : 12577-83.
  • Protective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis.

    Surjyo B et al (2004) Indian J Cancer 41(2) : 72-80.
  • Vitamin C as an antioxidant: evaluation of its role in disease prevention.

    Padayatty SJ et al (2003) J Am Coll Nutr 22(1) : 18-35.

3 Item(s)

Publications
These publications cite the use of L-Ascorbic acid purchased from Hello Bio:
  • In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk

    Salis et al (2022) Cardiff University : Thesis

1 Item