|Description|| Antioxidant. Enhances iPSC generation and increases reprogramming efficiency. Supports mesenchymal stem cell proliferation. |
|Alternative names|| L-Ascorbate |
|Biological description|| |
Naturally occurring antioxidant.
Enhances iPSC generation and increases reprogramming efficiency. Also supports mesenchymal stem cell proliferation and promotes differentiation of osteoblasts from human / mouse MSCs and mESCs.
Also a Cav3.2 channel inhibitor (IC50 = 6.5 µM) which exhibits little or no activity at Cav3.1 and Cav3.3 channels.
Commonly used with dexamethasone and β-Gly for osteogenic differentiation of stem cells.
Solubility & Handling
|Storage instructions|| Room temperature |
|Solubility overview|| Soluble in water (500mM) and in DMSO (100mM) |
|Important|| This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
|Chemical name|| 3-Oxo-L-gulofuranolactone |
|Chemical structure|| |
|PubChem identifier|| 54670067 |
|SMILES|| C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O |
|InChi|| InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1 |
|InChiKey|| CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
References for L-Ascorbic acid
References are publications that support the biological activity of the product
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.
Nelson MT et al (2007) J Neurosci 27(46) : 12577-83.
Protective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis.
Surjyo B et al (2004) Indian J Cancer 41(2) : 72-80.
Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Padayatty SJ et al (2003) J Am Coll Nutr 22(1) : 18-35.
These publications cite the use of L-Ascorbic acid purchased from Hello Bio:
In vitro modelling of human microglial alterations associated with Alzheimer's disease and polygenic risk
Salis et al (2022) Cardiff University : Thesis