Potent reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 µM). Activates AMPK allosterically and inhibits AMPK dephosphorylation. Also Na+ - K+- ATPase inhibitor (IC50 values are 57 and 220 µM for rat and human respectively). Stimulates glucose uptake and decreases fatty acid synthase levels. Additionally shown to inhibit MSC proliferation.
Solubility & Handling
Soluble in DMSO (100 mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.