Product overview

Name A 769662
Purity >98%
Description Potent, reversible AMPK activator. Inhibits MSC proliferation.
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Biological Data

Biological description Potent reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 µM). Activates AMPK allosterically and inhibits AMPK dephosphorylation. Also Na+ - K+- ATPase inhibitor (IC50 values are 57 and 220 µM for rat and human respectively). Stimulates glucose uptake and decreases fatty acid synthase levels. Additionally shown to inhibit MSC proliferation.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Molecular Weight 360.39
Chemical structure A 769662  [844499-71-4] Chemical Structure
Molecular Formula C20H12N2O3S
CAS Number 844499-71-4
PubChem identifier 54708532
SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
InChi InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)

References for A 769662

References are publications that support the biological activity of the product
  • Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

    Guigas B et al (2009) IUBMB Life 61(1) : 18-26.
  • AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

    Benziane B et al (2009) Am J Physiol Cell Physiol 297(6) : C1554-66.
  • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

    Cool B et al (2006) Cell Metab 3(6) : 403-16.

3 Item(s)