Product overview

Name A 769662
Description Potent, reversible AMPK activator. Inhibits MSC proliferation.
Purity >98%
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Biological Data

Biological description Potent reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 µM). Activates AMPK allosterically and inhibits AMPK dephosphorylation. Also Na+ - K+- ATPase inhibitor (IC50 values are 57 and 220 µM for rat and human respectively). Stimulates glucose uptake and decreases fatty acid synthase levels. Additionally shown to inhibit MSC proliferation.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Molecular Weight 360.39
Chemical structure A 769662  [844499-71-4] Chemical Structure
Molecular Formula C20H12N2O3S
CAS Number 844499-71-4
PubChem identifier 54708532
SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
InChi InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
InChiKey CTESJDQKVOEUOY-UHFFFAOYSA-N

References for A 769662

References are publications that support the biological activity of the product
  • Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

    Guigas B et al (2009) IUBMB Life 61(1) : 18-26.
  • AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

    Benziane B et al (2009) Am J Physiol Cell Physiol 297(6) : C1554-66.
  • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

    Cool B et al (2006) Cell Metab 3(6) : 403-16.