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A 769662

(HB1351)
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Product overview

Name A 769662
Purity >98%
Description Potent, reversible AMPK activator. Inhibits MSC proliferation.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description Potent reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 µM). Activates AMPK allosterically and inhibits AMPK dephosphorylation. Also Na+ - K+- ATPase inhibitor (IC50 values are 57 and 220 µM for rat and human respectively). Stimulates glucose uptake and decreases fatty acid synthase levels. Additionally shown to inhibit MSC proliferation.

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Molecular Weight 360.39
Chemical structure A 769662 [844499-71-4] Chemical Structure
Molecular Formula C20H12N2O3S
CAS Number 844499-71-4
PubChem identifier 54708532
SMILES C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
InChi InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
InChiKey CTESJDQKVOEUOY-UHFFFAOYSA-N

References for A 769662

References are publications that support the biological activity of the product

  • Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

    Guigas B et al (2009) IUBMB Life 61(1) : 18-26.
    Read more (PubMedID: 18798311)

  • AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

    Benziane B et al (2009) Am J Physiol Cell Physiol 297(6) : C1554-66.
    Read more (PubMedID: 19828836)

  • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

    Cool B et al (2006) Cell Metab 3(6) : 403-16.
    Read more (PubMedID: 16753576)

3 Item(s)

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Order: HB1351
Pack PriceQty
10mg
$209
50mg
$841
Potent, reversible AMPK activator. Inhibits MSC proliferation.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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