Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Go 6983 (HB0303)

    Description:

    Broad spectrum PKC inhibitor. Optimizes naïve human pluripotent stem cell growth and viability

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $34
    Qty:
    Pack:
    5mg
    Price:
    $160
    Qty:
    Pack:
    10mg
    Price:
    $240
    Qty:
  2. 1  Review
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    Description:

    Potent, non-selective kinase inhibitor.Also improves dissociate hESCs survival and clonogenicity.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $147
    Qty:
    Pack:
    50mg
    Price:
    $622
    Qty:
  3. Description:

    BET bromodomain inhibitor, also promotes differentiation of hiPSCs into megakaryocytes

    Purity:

    >98%

    Pack:
    50mg
    Price:
    $1,254
    Qty:
  4. IBMX (HB3000)

    Description:

    Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.

    Purity:

    >98%

    Pack:
    100mg
    Price:
    Qty:
    Pack:
    500mg
    Price:
    $138
    Qty:
  5. Pack:
    10mg
    Price:
    $192
    Qty:
    Pack:
    25mg
    Price:
    $376
    Qty:
  6. Pack:
    10mg
    Price:
    $171
    Qty:
  7. IQ 1 (HB3282)

    Description:

    Wnt pathway activator. Maintains ESC pluripotency in Wnt3a treated cells.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $188
    Qty:
    Pack:
    50mg
    Price:
    $726
    Qty:
  8. ISX 9 (HB3401)

    Description:

    Neurogenic agent. Induces SVZ progenitor neuronal differentiation and cardiomyogenic differentiation.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $193
    Qty:
  9. ITD 1 (HB3446)

    Description:

    Selective TGF-β signaling inhibitor. Induces cardiomyocyte differentiation in ESCs.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $215
    Qty:
    Pack:
    50mg
    Price:
    $832
    Qty:
  10. IWP 2 (HB0344)

    Description:

    Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $370
    Qty:
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