Product overview

Name AMD 3100 octahydrochloride
Description Potent, selective CXCR4 antagonist. Mobilizes hematopoietic stem cells.
Biological description Potent and selective CXCR4 antagonist (IC50 values are 0.79 and 0.18 at CXCR4 and CCR2 respectively). Blocks the route of HIV entry into T-cells. Shows potent anti-HIV activity in vitro and in vivo. Also mobilizes hematopoietic stem cells.
Alternative names Plerixafor | JM3100
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 1,1'-[1,4-Phenylenebis-(methylene)]- bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride
Molecular Weight 794.48
Chemical structure Product image
Molecular Formula C28H54N8.8HCl
CAS Number 155148-31-5
PubChem identifier 65014

References for AMD 3100 octahydrochloride

References are publications that support the biological activity of the product
  • Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.

    Bridger et al (1995) J Med Chem 38(2) : 366-78
  • Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.

    Fricker et al (2006) Biochem Pharmacol 72(5) : 588-96
  • Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization defective CD26-/- mice through AMD3100-induced disruption of the CXCL12-CXCR4 axis.

    Paganessi (2011) Exp Hematol 39(3) : 384-90