Product overview
| Name | (±)-Bay K 8644 |
| Description | L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts. |
| Purity | >99% |
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Biological Data
| Biological description | L-type Ca2+ channel agonist. Causes reduced inotropy in the myocardium. Also aids induced pluripotent stem cell generation from mouse embryonic fibroblasts (MEFs). Shows convulsive and vasoconstrictive actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester |
| Molecular Weight | 356.3 |
| Chemical structure | ![(±)-Bay K 8644 [71145-03-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1209.png "(±)-Bay K 8644 [71145-03-4]") |
| Molecular Formula | C16H15F3N2O4 |
| CAS Number | 71145-03-4 |
| PubChem identifier | 2303 |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O |
| InChi | InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3 |
| InChiKey | ZFLWDHHVRRZMEI-UHFFFAOYSA-N |
| MDL number | MFCD00036697 |
| Appearance | Yellow solid |
References for (±)-Bay K 8644
References are publications that support the biological activity of the product
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Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.
Chen X et al (2008) Am J Physiol Heart Circ Physiol 294(5) : H2257-67. -
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.
Shin EJ et al (2004) Behav Brain Res 151(1-2) : 267-76. -
Activation of protein kinase C by 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II cells.
Sen N et al (1997) Biochem Pharmacol 53(9) : 1307-13.
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