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(±)-Bay K 8644

(HB1209)
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Product overview

Name (±)-Bay K 8644
Purity >99%
Description L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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(±)-Bay K 8644 product vial image | Hello Bio
(±)-Bay K 8644 product vial image | Hello Bio

(±)-Bay K 8644 product vial image | Hello Bio

(±)-Bay K 8644 product vial image | Hello Bio

Biological Data

Biological description L-type Ca2+ channel agonist. Causes reduced inotropy in the myocardium. Also aids induced pluripotent stem cell generation from mouse embryonic fibroblasts (MEFs). Shows convulsive and vasoconstrictive actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Molecular Weight 356.3
Chemical structure (±)-Bay K 8644 [71145-03-4] Chemical Structure
Molecular Formula C16H15F3N2O4
CAS Number 71145-03-4
PubChem identifier 2303
SMILES COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O
InChi InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
InChiKey ZFLWDHHVRRZMEI-UHFFFAOYSA-N
MDL number MFCD00036697
Appearance Yellow solid

References for (±)-Bay K 8644

References are publications that support the biological activity of the product

  • Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.

    Chen X et al (2008) Am J Physiol Heart Circ Physiol 294(5) : H2257-67.
    Read more (PubMedID: 18359894)

  • Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.

    Shin EJ et al (2004) Behav Brain Res 151(1-2) : 267-76.
    Read more (PubMedID: 15084442)

  • Activation of protein kinase C by 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II cells.

    Sen N et al (1997) Biochem Pharmacol 53(9) : 1307-13.
    Read more (PubMedID: 9214691)

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Order: HB1209
Pack PriceQty
10mg
$130
50mg
$539
L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts.
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