Product overview

Name (±)-Bay K 8644
Description L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts.
Purity >99%
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Biological Data

Biological description L-type Ca2+ channel agonist. Causes reduced inotropy in the myocardium. Also aids induced pluripotent stem cell generation from mouse embryonic fibroblasts (MEFs). Shows convulsive and vasoconstrictive actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Molecular Weight 356.3
Chemical structure (±)-Bay K 8644  [71145-03-4] Chemical Structure
Molecular Formula C16H15F3N2O4
CAS Number 71145-03-4
PubChem identifier 2303
SMILES COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O
InChi InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
MDL number MFCD00036697
Appearance Yellow solid

References for (±)-Bay K 8644

References are publications that support the biological activity of the product
  • Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.

    Chen X et al (2008) Am J Physiol Heart Circ Physiol 294(5) : H2257-67.
  • Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.

    Shin EJ et al (2004) Behav Brain Res 151(1-2) : 267-76.
  • Activation of protein kinase C by 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II cells.

    Sen N et al (1997) Biochem Pharmacol 53(9) : 1307-13.