Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Description:

    LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.

    Purity:

    >98%

    Pack:
    250mg
    Price:
    $293
    Qty:
  2. Trichostatin A (HB1402)

    Description:

    Potent HDAC inhibitor. Induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $305
    Qty:
  3. Troglitazone (HB2559)

    Description:

    Potent, selective PPARγ agonist. Inhibits hematopoietic cell line growth.

    Purity:

    >97%

    Pack:
    25mg
    Price:
    $330
    Qty:
  4. Pack:
    1mg
    Price:
    Qty:
    Pack:
    5mg
    Price:
    $171
    Qty:
    Pack:
    25mg
    Price:
    $708
    Qty:
  5. Description:

    Histone deacetylase inhibitor. Shows multitude of biological actions. Enables pluripotent stem cell induction from somatic cells.

    Pack:
    10g
    Price:
    $53
    Qty:
  6. Description:

    Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $76
    Qty:
    Pack:
    50mg
    Price:
    $287
    Qty:
  7. WHI-P 154 (HB1431)

    Description:

    Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $85
    Qty:
    Pack:
    25mg
    Price:
    $307
    Qty:
  8. Pack:
    5mg
    Price:
    $94
    Qty:
    Pack:
    25mg
    Price:
    $365
    Qty:
  9. Wnt-C59 (HB3155)

    Description:

    Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $271
    Qty:
    Pack:
    50mg
    Price:
    $1,056
    Qty:
  10. XAV 939 (HB0660)

    Description:

    Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    Qty:
    Pack:
    10mg
    Price:
    $115
    Qty:
    Pack:
    25mg
    Price:
    $257
    Qty:
    Pack:
    50mg
    Price:
    $465
    Qty:
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