Histone deacetylase inhibitor (IC50 = 400 µM at HDAC1). Shows multitude of biological actions. Can be used to produce pluripotent stem cells (iPS cells) with only Oct4 and Sox2 factors required in addition. Activates Wnt-dependent gene expression and shows anti-inflammatory, anti-cancer anti-epileptic and neuroprotective actions. Blood-brain barrier permeable.
Solubility & Handling
Solubility overview
Soluble in water (100mM) or DMSO (50mM)
Storage instructions
room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines.
Shirsath N et al (2013) Lung Cancer 82(2) : 214-21.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Valproic acid sodium salt [1069-66-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0867.png "Valproic acid sodium salt [1069-66-5]")
Understanding purity and quality - a guide for life scientists
