Product overview

Name Valproic acid sodium salt
Alternative names VPA
Description Histone deacetylase inhibitor. Shows multitude of biological actions. Enables pluripotent stem cell induction from somatic cells.
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Biological Data

Biological description Histone deacetylase inhibitor (IC50 = 400 µM at HDAC1). Shows multitude of biological actions. Can be used to produce pluripotent stem cells (iPS cells) with only Oct4 and Sox2 factors required in addition. Activates Wnt-dependent gene expression and shows anti-inflammatory, anti-cancer anti-epileptic and neuroprotective actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name Sodium 2-propylpentanoate
Molecular Weight 166.19
Chemical structure Valproic acid sodium salt  [1069-66-5] Chemical Structure
Molecular Formula C8H15NaO2
CAS Number 1069-66-5
PubChem identifier 16760703

References for Valproic acid sodium salt

References are publications that support the biological activity of the product
  • Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines.

    Shirsath N et al (2013) Lung Cancer 82(2) : 214-21.
  • Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.

    Qing H et al (2008) J Exp Med 205(12) : 2781-9.
  • Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

    Huangfu D et al (2008) Nat Biotechnol 26(11) : 1269-75.
  • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.

    Phiel CJ et al (2001) J Biol Chem 276(39) : 36734-41.

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