Histone deacetylase inhibitor (IC50 = 400 µM at HDAC1). Shows multitude of biological actions. Can be used to produce pluripotent stem cells (iPS cells) with only Oct4 and Sox2 factors required in addition. Activates Wnt-dependent gene expression and shows anti-inflammatory, anti-cancer anti-epileptic and neuroprotective actions. Blood-brain barrier permeable.
Solubility & Handling
room temperature (desiccate)
Soluble in water (100mM) or DMSO (50mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines.
Shirsath N et al (2013) Lung Cancer 82(2) : 214-21.