Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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    $127
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  2. SP600125 (HB2234)

    Description:

    Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.

    Purity:

    >98%

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    10mg
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  3. Pack:
    10mg
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    $249
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    50mg
    Price:
    $978
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  4. Stauprimide (HB3011)

    Description:

    NME2 nuclear translocation inhibitor. Primes ESCs for differentiation.

    Purity:

    >98%

    Pack:
    100μg
    Price:
    $194
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    Description:

    Calcium sensing receptor (CaSR) agonist. Induces MSC osteogenic differentiation.

    Pack:
    1g
    Price:
    $106
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  6. SU 5402 (HB3133)

    Description:

    Potent FGFR and VEGFR inhibitor. Attenuates integrin β4-induced neural stem cell differentiation.

    Purity:

    >95%

    Pack:
    1mg
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    Pack:
    5mg
    Price:
    $144
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  7. Description:

    Thyroid hormone. Frequently used in various stem cell protocols.

    Purity:

    >98%

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    50mg
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    Pack:
    100mg
    Price:
    $59
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    250mg
    Price:
    $145
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  8. Pack:
    250mg
    Price:
    $309
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  9. Thiazovivin (HB3240)

    Description:

    Rock inhibitor. Improves hESCs survival and fibroblast reprogramming efficiency and iPSCs induction.

    Purity:

    >97%

    Pack:
    10mg
    Price:
    $422
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    Pack:
    25mg
    Price:
    $673
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  10. Trans-ISRIB (HB4567)

    Description:

    Integrated stress response (ISR) inhibitor. Promotes pluripotent stem cell survival as part of the CEPT cocktail.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $126
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    50mg
    Price:
    $433
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