The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Biological Data Biological description Potent histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 2, 6, 8 and 5 (IC50 values are 0.4, 1, 1.3, 2, 90 and 520 nM respectively). Shows anti-proliferative and anti-cancer actions.
Also induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (50mM) and in ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2E ,4E ,6R )-7-(4-(Dimethylamino)phen yl)-N -hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamid e
Chemical structure
Molecular Formula C17 H22 N2 O3
PubChem identifier 444732
SMILES C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChi InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChiKey RTKIYFITIVXBLE-QEQCGCAPSA-N
References for Trichostatin A References are publications that support the biological activity of the product
Synapse microarray identification of small molecules that enhance synaptogenesis. Shi P et al (2011) Nat Commun 2 : 510 Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Vigushin DM et al (2001) Clin Cancer Res 7(4) : 971-6. Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. Wharton W et al (2000) J Biol Chem 275(43) : 33981-7.
Publications
These publications cite the use of Trichostatin A purchased from Hello Bio:
Memory and plasticity impairment after binge drinking in adolescent rat hippocampus: GluN2A/GluN2B NMDA receptor subunits imbalance through HDAC2 Drissi I et al (2019) Addict Biol : e12760
Potent HDAC inhibitor. Induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.
![Trichostatin A [58880-19-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1402.png "Trichostatin A [58880-19-6]")
Understanding purity and quality - a guide for life scientists
