Potent histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 2, 6, 8 and 5 (IC50 values are 0.4, 1, 1.3, 2, 90 and 520 nM respectively). Shows anti-proliferative and anti-cancer actions.
Also induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM) and in ethanol (10mM)
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes.
Wharton W et al (2000) J Biol Chem 275(43) : 33981-7.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Trichostatin A [58880-19-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1402.png "Trichostatin A [58880-19-6]")
Understanding purity and quality - a guide for life scientists
