Product overview

Name Trichostatin A
Alternative names TSA
Purity >98%
Description Potent HDAC inhibitor. Induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.
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Biological Data

Biological description

Potent histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 2, 6, 8 and 5 (IC50 values are 0.4, 1, 1.3, 2, 90 and 520 nM respectively). Shows anti-proliferative and anti-cancer actions.

Also induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (50mM) and in ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (2E,4E,6R)-7-(4-(Dimethylamino)phen yl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamid e
Molecular Weight 302.37
Chemical structure Trichostatin A  [58880-19-6] Chemical Structure
Molecular Formula C17H22N2O3
CAS Number 58880-19-6
PubChem identifier 444732
SMILES C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChi InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
MDL number MFCD03848392

References for Trichostatin A

References are publications that support the biological activity of the product
  • Synapse microarray identification of small molecules that enhance synaptogenesis.

    Shi P et al (2011) Nat Commun 2 : 510
  • Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

    Vigushin DM et al (2001) Clin Cancer Res 7(4) : 971-6.
  • Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes.

    Wharton W et al (2000) J Biol Chem 275(43) : 33981-7.

3 Item(s)

These publications cite the use of Trichostatin A purchased from Hello Bio:
  • Memory and plasticity impairment after binge drinking in adolescent rat hippocampus: GluN2A/GluN2B NMDA receptor subunits imbalance through HDAC2

    Drissi I et al (2019) Addict Biol : e12760
    PubMedID: 31056842

1 Item