XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM at TNKS2 and TNKS1 respectively). Recently it has been indicated that XAV 939 also inhibits multiple PARP family proteins.
XAV 939 antagonizes Wnt signaling by stabilizing axin to stimulate β-catenin degradation.
XAV 939 also displays antiproliferative and apoptotic inducing properties.
References are publications that support the biological activity of the product
Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease.
Zhao JW et al (2014) Dis Model Mech 7(10) : 1193-203.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![XAV 939 [284028-89-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0660.png "XAV 939 [284028-89-3]")
Understanding purity and quality - a guide for life scientists
