Product overview

Name XAV 939
Purity >98%
Description Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.
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Biological Data

Biological description

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM at TNKS2 and TNKS1 respectively). Recently it has been indicated that XAV 939 also inhibits multiple PARP family proteins.

XAV 939 antagonizes Wnt signaling by stabilizing axin to stimulate β-catenin degradation.

XAV 939 also displays antiproliferative and apoptotic inducing properties.

XAV 939 robustly induces cardiomyogenesis in mouse embryonic stem (ES) cells.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Molecular Weight 312.31
Chemical structure XAV 939  [284028-89-3] Chemical Structure
Molecular Formula C14H11F3N2OS
CAS Number 284028-89-3
PubChem identifier 2726824
Source Synthetic
InChi InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
MDL number MFCD16879017

References for XAV 939

References are publications that support the biological activity of the product
  • Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease.

    Zhao JW et al (2014) Dis Model Mech 7(10) : 1193-203.
  • XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1.

    Tian X et al (2014) Int J Oncol 45(1) : 121-8.
  • XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway.

    Tian XH et al (2013) J Exp Clin Cancer Res 32 : 100
  • Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.

    Kirby CA et al (2012) Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 2) : 115-8.

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