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Biological Data Biological description Lysine-specific demethylase 1 (LSD1) and monoamine oxidase (MAO) inhibitor (IC50 = < 2 µM for LSD1). Irreversible inhibition of LSD1, inhibits H3K4 demethylation. Enables reprogramming of mouse embryonic fibroblasts into iPS cells. Shows antidepressant actions.
Solubility & Handling Storage instructions room temperature (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (±)-trans -2-Phenylcyclopropylamine hydrochloride
Chemical structure
Molecular Formula C9 H11 N.HCl
PubChem identifier 2723716
SMILES N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl
InChiKey ZPEFMSTTZXJOTM-OULXEKPRSA-N
References for Tranylcypromine hydrochloride References are publications that support the biological activity of the product
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Li W et al (2009) Stem Cells 27(12) : 2992-3000. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Schmidt DM et al (2007) Biochemistry 46(14) : 4408-16. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Lee MG et al (2006) Chem Biol 13(6) : 563-7. Tranylcypromine: new perspectives on an 'old' drug. Frieling H et al (2006) Eur Arch Psychiatry Clin Neurosci 256(5) : 268-73.
LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.
![Tranylcypromine hydrochloride [1986-47-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1412.png "Tranylcypromine hydrochloride [1986-47-6]")
Understanding purity and quality - a guide for life scientists
