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Tranylcypromine hydrochloride

(HB1412)
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Product overview

Name Tranylcypromine hydrochloride
Alternative names trans-2-phenylcyclopropylamine; 2-PCPA; Parnate
Purity >98%
Description LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Lysine-specific demethylase 1 (LSD1) and monoamine oxidase (MAO) inhibitor (IC50 = < 2 µM for LSD1). Irreversible inhibition of LSD1, inhibits H3K4 demethylation. Enables reprogramming of mouse embryonic fibroblasts into iPS cells. Shows antidepressant actions.

Solubility & Handling

Solubility overview Soluble in water (100mM) or DMSO (100mM)
Storage instructions room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (±)-trans-2-Phenylcyclopropylamine hydrochloride
Molecular Weight 169.65
Chemical structure Tranylcypromine hydrochloride [1986-47-6] Chemical Structure
Molecular Formula C9H11N.HCl
CAS Number 1986-47-6
PubChem identifier 2723716
SMILES N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl
InChiKey ZPEFMSTTZXJOTM-OULXEKPRSA-N

References for Tranylcypromine hydrochloride

References are publications that support the biological activity of the product

  • Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.

    Li W et al (2009) Stem Cells 27(12) : 2992-3000.
    Read more (PubMedID: 19839055)

  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

    Schmidt DM et al (2007) Biochemistry 46(14) : 4408-16.
    Read more (PubMedID: 17367163)

  • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.

    Lee MG et al (2006) Chem Biol 13(6) : 563-7.
    Read more (PubMedID: 16793513)

  • Tranylcypromine: new perspectives on an 'old' drug.

    Frieling H et al (2006) Eur Arch Psychiatry Clin Neurosci 256(5) : 268-73.
    Read more (PubMedID: 16927039)

4 Item(s)

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Grouped product items
Order: HB1412
Pack PriceQty
250mg
$293
LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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