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U0126: Scientist Approved

Biological Data

Biological description Potent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC50 values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Molecular Weight 380.48
Chemical structure U0126 [109511-58-2] Chemical Structure
Molecular Formula C18H16N6S2
CAS Number 109511-58-2
PubChem identifier 3006531
SMILES C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
InChi InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChiKey DVEXZJFMOKTQEZ-JYFOCSDGSA-N
MDL number MFCD25977152

References for U0126

References are publications that support the biological activity of the product
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
  • Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.

    Duan W et al (2004) J Immunol 172(11) : 7053-9.
  • MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

    Duncia JV et al (1998) Bioorg Med Chem Lett 8(20) : 2839-44.
  • Identification of a novel inhibitor of mitogen-activated protein kinase kinase.

    Favata MF et al (1998) J Biol Chem 273(29) : 18623-32.

4 Item(s)

Publications
These publications cite the use of U0126 purchased from Hello Bio:
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245

1 Item