Product overview
| Name | U0126 |
| Description | Potent, selective MEK-1/MEK-2 inhibitor |
| Purity | >99% |
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Biological Data
| Biological description | Potent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC50 values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >99% |
| Chemical name | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
| Molecular Weight | 380.48 |
| Chemical structure | ![U0126 [109511-58-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2246.png "U0126 [109511-58-2]") |
| Molecular Formula | C18H16N6S2 |
| CAS Number | 109511-58-2 |
| PubChem identifier | 3006531 |
| SMILES | C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
| InChi | InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ |
| InChiKey | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
| MDL number | MFCD25977152 |
References for U0126
References are publications that support the biological activity of the product
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Pre-LTP requires extracellular signal-regulated kinase in the ACC.
Yamanaka et al (2016) Mol Pain 12 : 1-12 -
Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.
Duan W et al (2004) J Immunol 172(11) : 7053-9. -
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.
Duncia JV et al (1998) Bioorg Med Chem Lett 8(20) : 2839-44. -
Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
Favata MF et al (1998) J Biol Chem 273(29) : 18623-32.
Publications
These publications cite the use of U0126 purchased from Hello Bio:
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Pre-LTP requires extracellular signal-regulated kinase in the ACC.
Yamanaka et al (2016) Mol Pain 12 : 1-12PubMedID: 27178245
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