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Images U0126: Scientist Approved
U0126: Scientist Approved Biological Data Biological description Potent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC50 values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo .
Solubility & Handling Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1,4-Diamino-2,3-dicyano-1,4-bis [2-aminophenylthio]butadiene
Chemical structure
Molecular Formula C18 H16 N6 S2
PubChem identifier 3006531
SMILES C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
InChi InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChiKey DVEXZJFMOKTQEZ-JYFOCSDGSA-N
References for U0126 References are publications that support the biological activity of the product
Pre-LTP requires extracellular signal-regulated kinase in the ACC. Yamanaka et al (2016) Mol Pain 12 : 1-12 Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. Duan W et al (2004) J Immunol 172(11) : 7053-9. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Duncia JV et al (1998) Bioorg Med Chem Lett 8(20) : 2839-44. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. Favata MF et al (1998) J Biol Chem 273(29) : 18623-32.
Publications
These publications cite the use of U0126 purchased from Hello Bio:
Pre-LTP requires extracellular signal-regulated kinase in the ACC. Yamanaka et al (2016) Mol Pain 12 : 1-12
Potent, selective MEK-1/MEK-2 inhibitor
![U0126 [109511-58-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb2246.png "U0126 [109511-58-2]")
Understanding purity and quality - a guide for life scientists
