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U0126

(HB2246)
Publications (1)
Technical documents: SDS Datasheet
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Product overview

Name U0126
Purity >99%
Description Potent, selective MEK-1/MEK-2 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews Publications (1) References (4) Frequently bought together
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U0126: Scientist Approved
U0126: Scientist Approved

U0126: Scientist Approved

U0126: Scientist Approved

Biological Data

Biological description Potent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC50 values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Molecular Weight 380.48
Chemical structure U0126 [109511-58-2] Chemical Structure
Molecular Formula C18H16N6S2
CAS Number 109511-58-2
PubChem identifier 3006531
SMILES C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
InChi InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChiKey DVEXZJFMOKTQEZ-JYFOCSDGSA-N
MDL number MFCD25977152

References for U0126

References are publications that support the biological activity of the product

  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    Read more (PubMedID: 27178245)

  • Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.

    Duan W et al (2004) J Immunol 172(11) : 7053-9.
    Read more (PubMedID: 15153527)

  • MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

    Duncia JV et al (1998) Bioorg Med Chem Lett 8(20) : 2839-44.
    Read more (PubMedID: 9873633)

  • Identification of a novel inhibitor of mitogen-activated protein kinase kinase.

    Favata MF et al (1998) J Biol Chem 273(29) : 18623-32.
    Read more (PubMedID: 9660836)

4 Item(s)

Publications
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These publications cite the use of U0126 purchased from Hello Bio:

  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245

1 Item

Related Products
Grouped product items
Order: HB2246
Pack PriceQty
1mg
$66
5mg
$171
25mg
$708
Potent, selective MEK-1/MEK-2 inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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