Product overview

Name WHI-P 154
Alternative names WHI-P154
Purity >99%
Description Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.
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Biological Data

Biological description Non-selective JAK3 inhibitor (IC50 = 1.8 µM), also acts as a potent EGFR kinase inhibitor (IC50 = 4 nM). Inhibits expression of iNOS and production of NO. Also induces neural progenitor cell differentiation. Shows apoptotic and anti-tumor actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
Molecular Weight 376.2
Chemical structure WHI-P 154  [211555-04-3] Chemical Structure
Molecular Formula C16H14BrN3O3
CAS Number 211555-04-3
PubChem identifier 3795

References for WHI-P 154

References are publications that support the biological activity of the product
  • The specificity of JAK3 kinase inhibitors.

    Changelian PS et al (2008) Blood 111(4) : 2155-7.
  • Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.

    Sareila O et al (2008) Int Immunopharmacol 8(1) : 100-8.
  • 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.

    Narla RK et al (1998) Clin Cancer Res 4(6) : 1405-14.

3 Item(s)