Product overview
| Name | WHI-P 154 |
| Alternative names | WHI-P154 |
| Purity | >99% |
| Description | Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation. |
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Biological Data
| Biological description | Non-selective JAK3 inhibitor (IC50 = 1.8 µM), also acts as a potent EGFR kinase inhibitor (IC50 = 4 nM). Inhibits expression of iNOS and production of NO. Also induces neural progenitor cell differentiation. Shows apoptotic and anti-tumor actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >99% |
| Chemical name | 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol |
| Molecular Weight | 376.2 |
| Chemical structure | ![WHI-P 154 [211555-04-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1431.png "WHI-P 154 [211555-04-3]") |
| Molecular Formula | C16H14BrN3O3 |
| CAS Number | 211555-04-3 |
| PubChem identifier | 3795 |
| SMILES | OC(C=C3)=C(Br)C=C3NC2=NC=NC1=CC(OC)=C(OC)C=C12 |
| InChiKey | CBIAKDAYHRWZCU-UHFFFAOYSA-N |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for WHI-P 154
References are publications that support the biological activity of the product
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The specificity of JAK3 kinase inhibitors.
Changelian PS et al (2008) Blood 111(4) : 2155-7. -
Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.
Sareila O et al (2008) Int Immunopharmacol 8(1) : 100-8. -
4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.
Narla RK et al (1998) Clin Cancer Res 4(6) : 1405-14.
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