Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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    Description:

    Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

    Purity:

    >99%

    Pack:
    1mg
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    $46
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    2mg
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    5mg
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    $124
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    10mg
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    $175
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    5x10mg
    Price:
    $786
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    25mg
    Price:
    $339
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    50mg
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    $588
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    10mM solution (in 1mL DMSO)
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    $180
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    50mM (add 1ml water)
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    $426
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    100mM (add 1ml water)
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    $710
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  2. Zebularine (HB1378)

    Description:

    DNA methyltransferase inhibitor. Induces cardiomyocyte differentiation in MSCs.

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $43
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    5mg
    Price:
    $92
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