Potent, cell permeable PORCN inhibitor (IC50 = 74 pM). >100-fold more potent than IWP1. Potently inhibits Wnt/β-catenin signaling. Also induces induced pluripotent stem cell (iPSC) cardiomyocyte differentiation when used in combination with CHIR 99021.
Solubility & Handling
Solubility overview
Soluble in DMSO (20mM) or ethanol (20mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Youssef et al (24930130) Nat Cell Biol 14(12) : 1282-94
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Wnt-C59 | [1243243-89-1] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb3155.png "Wnt-C59 | [1243243-89-1]")
Understanding purity and quality - a guide for life scientists
