Product overview

Name Wnt-C59
Purity >99%
Description Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation.
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Biological Data

Biological description Potent, cell permeable PORCN inhibitor (IC50 = 74 pM). >100-fold more potent than IWP1. Potently inhibits Wnt/β-catenin signaling. Also induces induced pluripotent stem cell (iPSC) cardiomyocyte differentiation when used in combination with CHIR 99021.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (20mM) or ethanol (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 4-(2-Methyl-4-pyridinyl)-N-[4-(3-py ridinyl)phenyl]benzeneacetamide
Molecular Weight 379.45
Chemical structure Wnt-C59 |  [1243243-89-1] Chemical Structure
Molecular Formula C25H21N3O
CAS Number 1243243-89-1
PubChem identifier 57519544

References for Wnt-C59

References are publications that support the biological activity of the product
  • Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.

    Youssef et al (24930130) Nat Cell Biol 14(12) : 1282-94
  • Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

    Proffitt et al (2013) Cancer Res 73(2) : 502-7
  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

    Chen et al (2009) Nat Chem Biol 5(2) : 100-7

3 Item(s)

These publications cite the use of Wnt-C59 purchased from Hello Bio:
  • The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair

    Kim SY et al (2021) Biomaterials 267 : 120480
    PubMedID: 33157373

1 Item