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WIKI4

(HB0657)
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Product overview

Name WIKI4
Purity >98%
Description Potent tankyrase inhibitor. Wnt signaling inhibitor.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (2) Frequently bought together
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Biological Data

Biological description Potent tankyrase (TNKS) inhibitor (IC50 values are 15 and 26 nM for TNKS2 and TNKS1 respectively). Inhibits the auto-ADP-ribosylation of tankyrase and Wnt/β-catenin signaling in cancer cell lines and embryonic stem cells (EC50 = 75 nM).

Solubility & Handling

Solubility overview Soluble in DMSO (20mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyr idinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz [de]isoquinoline-1,3(2H)-dione
Molecular Weight 521.59
Chemical structure WIKI4 [838818-26-1] Chemical Structure
Molecular Formula C29H23N5O3S
CAS Number 838818-26-1
PubChem identifier 2984337
SMILES O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2
InChiKey RNUXIZKXJOGYQP-UHFFFAOYSA-N

References for WIKI4

References are publications that support the biological activity of the product

  • Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.

    Haikarainen T et al (2013) PLoS One 8(6) : e65404.
    Read more (PubMedID: 23762361)

  • WIKI4, a novel inhibitor of tankyrase and Wnt/ã?-catenin signaling.

    James RG et al (2012) PLoS One 7(12) : e50457.
    Read more (PubMedID: 23227175)

2 Item(s)

Related Products
Grouped product items
Order: HB0657
Pack PriceQty
5mg
$94
25mg
$365
Potent tankyrase inhibitor. Wnt signaling inhibitor.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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