Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  2. Anisomycin (HB2239)

    Description:

    Protein synthesis inhibitor. Potent JNK / p38 MAPK activator.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $75
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    50mg
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    $291
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    100mg
    Price:
    $513
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  3. Description:

    Antibody to Calbindin - calcium binding protein used as a marker for an inhibitory interneuron subtype. Part of the ValidAbâ„¢ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Rat
    Pack:
    25μg
    Price:
    $150
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    Pack:
    100μg
    Price:
    $336
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  4. Description:

    Antibody to GFAP - cytoskeletal protein used as an astrocyte marker. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Goat
    Clonality: Polyclonal
    Reactivity Tested: Mouse, Rat
    Pack:
    25μg
    Price:
    $197
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    100μg
    Price:
    $442
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  5. Description:

    Antibody to the GluN1 subunit of the NMDA receptor. Part of the ValidAbâ„¢ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Mouse, Rat
    Pack:
    3μg
    Price:
    $131
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    Pack:
    15μg
    Price:
    $457
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  6. Description:

    Antibody to MAP2 - cytoskeletal protein used as a neuronal marker. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Chicken
    Clonality: Polyclonal
    Reactivity Tested: Mouse, Rat
    Pack:
    25μL
    Price:
    $240
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    Pack:
    50μL
    Price:
    $370
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  7. Description:

    Antibody to NeuN - marker for mature neurones expressed in the nucleus. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Goat
    Clonality: Polyclonal
    Reactivity Tested: Mouse, Rat
    Pack:
    25μg
    Price:
    $144
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    Pack:
    100μg
    Price:
    $320
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  8. Pack:
    50mg
    Price:
    $48
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  9. L-AP4 (HB0370)

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    Description:

    L-AP4 is a selective group III mGluR agonist which inhibits synaptic transmission.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $102
    Free trial
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    10mg
    Price:
    $197
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    25mg
    Price:
    $411
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    50mg
    Price:
    $816
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