Protein synthesis inhibitor which prevents elongation and causes polysome stabilization by binding to the 60S ribosomal subunit to prevent peptide bond formation.
Also acts as a potent JNK and p38 MAPK activator.
Initiates intracellular signals for rapid induction of immediate-early (IE) genes (e.g. c-fos, fosB, c-jun, JunB and JunD).
Additionally, thought to block late long-term potentiation (L-LTP) and at high doses reduces neuronal activity.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in ethanol (50 mM) and DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Croons et al (19286921) J Pharmacol Exp Ther 329(3) : 856-64
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