Protein synthesis inhibitor which prevents elongation and causes polysome stabilization by binding to the 60S ribosomal subunit to prevent peptide bond formation.
Also acts as a potent JNK and p38 MAPK activator.
Initiates intracellular signals for rapid induction of immediate-early (IE) genes (e.g. c-fos, fosB, c-jun, JunB and JunD).
Additionally, thought to block late long-term potentiation (L-LTP) and at high doses reduces neuronal activity.
Solubility & Handling
Solubility overview
Soluble in ethanol (50 mM) and DMSO (100 mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Croons et al (19286921) J Pharmacol Exp Ther 329(3) : 856-64
Understanding purity and quality - a guide for life scientists
