Product overview
| Name | Anisomycin |
| Description | Protein synthesis inhibitor. Potent JNK / p38 MAPK activator. |
| Alternative names | ANI | Flagecidin |
| Purity | >98% |
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Biological Data
| Biological description | Protein synthesis inhibitor which prevents elongation and causes polysome stabilization by binding to the 60S ribosomal subunit to prevent peptide bond formation. Also acts as a potent JNK and p38 MAPK activator.
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Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in ethanol (50 mM) and DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate |
| Molecular Weight | 265.31 |
| Molecular Formula | C14H19NO4 |
| CAS Number | 22862-76-6 |
| PubChem identifier | 253602 |
| SMILES | CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O |
| InChiKey | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
| MDL number | MFCD00077650 |
| Appearance | White to off-white |
References for Anisomycin
References are publications that support the biological activity of the product
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Effects of anisomycin on LTP in the hippocampal CA1: long-term analysis using optical recording.
Mochida et al (2001) Neuroreport 12(5) : 987-91 -
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
Hazzalin et al (1998) Mol Cell Biol. 18(4) : 1844-54. -
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Croons et al (19286921) J Pharmacol Exp Ther 329(3) : 856-64
Publications
These publications cite the use of Anisomycin purchased from Hello Bio:
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Investigating the Role of LIMK1 Signaling in PKA-dependent LTP in the Hippocampus
Cai, S. (2019) University of Toronto Thesis : 1-135 -
On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus.
Park et al (2019) Front Synaptic Neurosci. 14; : 11:4PubMedID: 30923499
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