Product overview

Name Anisomycin
Description Protein synthesis inhibitor. Potent JNK / p38 MAPK activator.
Alternative names ANI | Flagecidin
Purity >98%
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Biological Data

Biological description

Protein synthesis inhibitor which prevents elongation and causes polysome stabilization by binding to the 60S ribosomal subunit to prevent peptide bond formation.

Also acts as a potent JNK and p38 MAPK activator.


Initiates intracellular signals for rapid induction of immediate-early (IE) genes (e.g. c-fos, fosB, c-jun, JunB and JunD).


Additionally, thought to block late long-term potentiation (L-LTP) and at high doses reduces neuronal activity.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in ethanol (50 mM) and DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
Molecular Weight 265.31
Molecular Formula C14H19NO4
CAS Number 22862-76-6
PubChem identifier 253602
SMILES CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O
InChiKey YKJYKKNCCRKFSL-RDBSUJKOSA-N
MDL number MFCD00077650
Appearance White to off-white

References for Anisomycin

References are publications that support the biological activity of the product
  • Effects of anisomycin on LTP in the hippocampal CA1: long-term analysis using optical recording.

    Mochida et al (2001) Neuroreport 12(5) : 987-91
  • Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.

    Hazzalin et al (1998) Mol Cell Biol. 18(4) : 1844-54.
  • The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.

    Croons et al (19286921) J Pharmacol Exp Ther 329(3) : 856-64
Publications
These publications cite the use of Anisomycin purchased from Hello Bio:
  • Investigating the Role of LIMK1 Signaling in PKA-dependent LTP in the Hippocampus

    Cai, S. (2019) University of Toronto Thesis : 1-135
  • On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus.

    Park et al (2019) Front Synaptic Neurosci. 14; : 11:4
    PubMedID: 30923499

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