DL-AP4

(HB0249)
Technical documents: SDS CoA Datasheet

Product overview

Name DL-AP4
Description Broad spectrum glutamate antagonist
Alternative names 2-amino-4-phosphonobutyrate; 2APB
Purity >98%
Customer comments

Great Price! We are using this (DL-AP4) to block transmission through the ON-pathway in retinal bipolar cells; it seems to work well, and the price is great! Verified customer, Washington State University

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DL-AP4 - vial

Biological Data

Biological description Broad spectrum glutamate antagonist. Produces depolarizing responses in the cerebral cortex for a short time period after quisqualate application.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (33mM)

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name DL-2-Amino-4-phosphonobutyric acid
Molecular Weight 183.1
Chemical structure DL-AP4  [6323-99-5] Chemical Structure
Molecular Formula C4H10NO5P
CAS Number 6323-99-5
PubChem identifier 2207
SMILES C(CP(=O)(O)O)C(C(=O)O)N
Source Synthetic
InChi InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
InChiKey DDOQBQRIEWHWBT-UHFFFAOYSA-N
MDL number MFCD00013999
Appearance White solid

References for DL-AP4

References are publications that support the biological activity of the product
  • Anion transport blockers inhibit DL-2-amino-4-phosphonobutyrate responses induced by quisqualate in the rat cerebral cortex.

    Turner JP (1993) Br J Pharmacol 109(2) : 449-58.
  • The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations.

    Evans RH et al (1982) Br J Pharmacol 75(1) : 65-75.
  • Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog.

    Evans RH et al (1979) Br J Pharmacol 67(4) : 591-603.