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AP 18

(HB1157)
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Product overview

Name AP 18
Purity >98%
Description TRPA1 channel antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description TRPA1 channel antagonist (IC50 values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
Molecular Weight 209.67
Chemical structure AP 18 [55224-94-7] Chemical Structure
Molecular Formula C11H12ClNO
CAS Number 55224-94-7
PubChem identifier 9584673
SMILES ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1
InChiKey MHTJEUOFLVQMCL-NJHPPEEMSA-N

References for AP 18

References are publications that support the biological activity of the product

  • Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.

    Defalco J et al (2010) Bioorg Med Chem Lett 20(1) : 276-9.
    Read more (PubMedID: 19945872)

  • Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

    Taylor-Clark TE et al (2009) Mol Pharmacol 75(4) : 820-9.
    Read more (PubMedID: 19171673)

  • A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

    Petrus M et al (2007) Mol Pain 3 : 40
    Read more (PubMedID: 18086313)

3 Item(s)

Grouped product items
Order: HB1157
Pack PriceQty
25mg
$343
TRPA1 channel antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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