AP 18

Name: AP 18
SKU: HB1157
Price: 338 USD
Availability: InStock

(HB1157)

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Technical documents: Datasheet

Product overview

Name

AP 18

Purity

>98%

Description

TRPA1 channel antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3) Frequently bought together

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Biological Data

Biological description

TRPA1 channel antagonist (IC₅₀ values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.

Solubility & Handling

Storage instructions

+4°C

Solubility overview

Soluble in DMSO (100mM) or ethanol (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime

Molecular Weight

209.67

Chemical structure

Molecular Formula

C₁₁H₁₂ClNO

CAS Number

55224-94-7

PubChem identifier

9584673

SMILES

ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1

InChiKey

MHTJEUOFLVQMCL-NJHPPEEMSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for AP 18

References are publications that support the biological activity of the product

Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.
Defalco J et al (2010) Bioorg Med Chem Lett 20(1) : 276-9.
Read more (PubMedID: 19945872)
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.
Taylor-Clark TE et al (2009) Mol Pharmacol 75(4) : 820-9.
Read more (PubMedID: 19171673)
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.
Petrus M et al (2007) Mol Pain 3 : 40
Read more (PubMedID: 18086313)

TRPA1 channel antagonist

Order: HB1157
Pack	Price	Qty
25mg	$338

AP 18

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for AP 18

Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

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AP 18

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for AP 18

Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

About you

Tell us about your publication!

Captcha

About you

How can we help you?

New Products in this Area