TRPA1 channel antagonist (IC50 values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.
Solubility & Handling
Soluble in DMSO (100mM) or ethanol (100mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.