Cytokine Storm / Immune response signaling
Cytokine storm describes an excessive immune response to external stimuli with the release of a large amount of pro-inflammatory cytokines. Cytokine storms occur in a range of infections and non-infectious diseases including COVID-19. The cytokine storm involves a variety of immune-related molecules such as interferon, interleukins, chemokines, CSFs and TNF-α. Increase in proinflammatory cytokines results in an influx of immune cells such as macrophages, T-Cells and neutrophils. The immune response to SARS-CoV2 infection also involves various signaling pathways. Researchers can save up to 50% on small molecules that affect cytokine storm and the immune response, as they are up to half the price of other suppliers.
View products: Angiotensin related | Cytokines, chemokines & NF-κB/I-κB | Inflammasomes | JAK/STAT | MAPK Signaling | PI3K/Akt/mTOR | Protease-Activated Receptors | TLR signaling
Anti-GST tag antibody ValidAbTM (HB9897)
Description:Antibody to the GST tag - widely used as a protein tag in molecular biology. Part of the ValidAbâ„¢ range of highly validated, data-rich antibodies.Â
Host: MouseClonality: MonoclonalReactivity Tested: Species IndependentAnti-Histone H3 antibody ValidAbâ„¢ (HB6980)
Description:Antibody to Histone H3 - Histone protein used as a loading control for western blotting. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: RabbitClonality: PolyclonalReactivity Tested: Mouse, RatAnti-HSP60 antibody ValidAbâ„¢ (HB7863)
Description:Antibody to HSP60 - loading control and mitochondrial marker for immunohistochemistry and immunocytochemistry. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: MouseClonality: MonoclonalReactivity Tested: Mouse, Rat, Human10Z-Hymenialdisine (HB1264)
Description:Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
Purity:>97%
Anti-IBA1 antibody ValidAbTM (HB7847)
Description:Antibody to IBA1 - calcium binding protein widely used as a marker for microglial cells. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: RabbitClonality: PolyclonalReactivity Tested: Mouse, RatI-BET 151 hydrochloride (HB1446)
Description:BET bromodomain inhibitor, also promotes differentiation of hiPSCs into megakaryocytes
Purity:>98%
Jasplakinolide (HB3946)
Description:Cell permeable, non-fluorescent F-actin probe. Induces actin polymerization and stabilization.
Purity:>98%
(+)-JQ1 (HB1448)
Description:Potent, selective BET bromodomain inhibitor. Cell permeable.
Purity:>98%
Anti-Ki-67 antibody ValidAbTM (HB7052)
Description:Antibody to Ki-67 - a widely used marker of proliferating cells. Part of the ValidAb™ range of highly validated, data-rich antibodies.
Host: MouseClonality: MonoclonalReactivity Tested: Human