Histone deacetylase (HDAC)

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Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

Items 1-10 of 59

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  1. A 83-01 (HB3218)

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    Description:

    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $80
    Qty:
    Pack:
    25mg
    Price:
    $270
    Qty:
  2. AICAR (HB2152)

    Description:

    AMPK activator. Promotes osteogenic differentiation of bone marrow-derived MSCs.

    Purity:

    >99%

    Pack:
    25mg
    Price:
    $74
    Qty:
  3. Description:

    Phytohormone and endogenous lanthionine synthetase C-like 2 (LANCL2) ligand

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $126
    Qty:
    Pack:
    50mg
    Price:
    $553
    Qty:
  4. L-Ascorbic acid (HB1238)

    Description:

    Antioxidant. Enhances iPSC generation and increases reprogramming efficiency. Supports mesenchymal stem cell proliferation.

    Purity:

    >99%

    Pack:
    100mg
    Price:
    $78
    Qty:
    Pack:
    1g
    Price:
    $25
    Qty:
    Pack:
    25g
    Price:
    $38
    Qty:
    Pack:
    100g
    Price:
    $91
    Qty:
  5. 5-Azacytidine (HB1374)

    Description:

    DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.

    Purity:

    >98%

    Pack:
    50mg
    Price:
    $63
    Qty:
    Pack:
    250mg
    Price:
    $86
    Qty:
  6. Description:

    Member of the neurotrophin growth factor family. Plays an important role in synaptic plasticity and neurogenesis.

    Pack:
    2μg
    Price:
    $59
    Qty:
    Pack:
    10μg
    Price:
    $236
    Qty:
  7. CCG 1423 (HB3389)

    Description:

    Rho/SRF pathway inhibitor. Induces intermediate mesoderm differentiation from ESCs.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $104
    Qty:
    Pack:
    50mg
    Price:
    $382
    Qty:
  8. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $44
    Qty:
    Pack:
    5mg
    Price:
    $102
    Qty:
    Pack:
    10mg
    Price:
    $159
    Qty:
    Pack:
    25mg
    Price:
    $388
    Qty:
    Pack:
    50mg
    Price:
    $661
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $110
    Qty:
  9. Compound E (HB3849)

    Description:

    Potent, selective, non-competitive γ-secretase inhibitor. Induces neuronal differentiation.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $339
    Qty:
  10. Cyclopamine (HB2965)

    Description:

    Smo and hedgehog (Hh) signaling inhibitor. Also depletes stem like cancer cells and induces hESCs into endocrine cells.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $178
    Qty:
    Pack:
    5mg
    Price:
    $678
    Qty:
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