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Biological Data
| Biological description | Cell permeable, potent, selective, non-transition state and non-competitive gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity. |
Solubility & Handling
| Storage instructions | +4°C |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide |
| Chemical structure | ![Compound E [209986-17-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Compound E [209986-17-4]") |
| Molecular Formula | C27H24F2N4O3 |
| PubChem identifier | 11306390 |
| SMILES | C[C@@H](C(N[C@H]1N=C(C2=CC=CC=C2N(C1=O)C)C3=CC=CC=C3)=O)NC(CC4=CC(F)=CC(F)=C4)=O |
| InChiKey | JNGZXGGOCLZBFB-IVCQMTBJSA-N |
| Appearance | White to off-white solid |
Potent, selective, non-competitive γ-secretase inhibitor. Induces neuronal differentiation.
![Compound E [209986-17-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3849.png "Compound E [209986-17-4]")
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