Product overview

Name Cyclopamine
Description Smo and hedgehog (Hh) signaling inhibitor. Also depletes stem like cancer cells and induces hESCs into endocrine cells.
Biological description Smo Inhibitor and hedgehog (Hh) signaling inhibitor. Depletes stem like cancer cells and induces hESCs into endocrine cells. Blocks abnormal cell growth associated with fibroblast Ptch and Smo oncogenic mutations. Also induces apoptosis and arrests cell cycle at G0/G1 phase and depletes stem like cancer cells. Shows anticancer activity.
Purity >98%
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Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Molecular Weight 411.6
Chemical structure Product image
Molecular Formula C27H41NO2
CAS Number 4449-51-8
PubChem identifier 442972
SMILES O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@]([H])3CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])[C@@]([H])1CC3=[C@@]4C
InChiKey QASFUMOKHFSJGL-LAFRSMQTSA-N
Appearance White to off-white solid