Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
Potent, selective and ATP-competitive GSK-3 inhibitor (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively).
Wnt signaling activator which is commonly used with PD 032501 as part of the 2i inhibitor combination.
Exhibits no cross reactivity against CDKs and exhibits >500-fold selectivity for GSK3 over other protein kinases and >800-fold selectivity over >20 other enzymes and receptors.
Promotes self-renewal of embryonic stem cells and enables mouse embryonic fibroblast (MEF) reprogramming into iPSCs.
Commonly used in organoid production and also involved in reprogramming of fibroblasts to mature neurons.
References are publications that support the biological activity of the product
The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways.
Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
![CHIR 99021 [252917-06-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1261.png "CHIR 99021 [252917-06-9]")
Understanding purity and quality - a guide for life scientists
