Nuclear Receptors
Nuclear hormone receptors (nuclear receptors) are specialized transcription factors which bind to specific sequences of DNA of particular target genes. They regulate transcription of these target genes in response to a variety of endogenous ligands. Nuclear receptors are classified into two major subfamilies: steroid and non-steroid hormone receptors. Steroid hormone receptors include receptors for estrogen (ER), androgen, glucocorticoid, mineralocorticoid and progesterone. Examples of non-steroid hormone receptors include thyroid receptors, retinoic acid receptors and peroxisome proliferator-activated receptors (PPAR). Researchers can make big savings on Hello Bio's Nuclear Receptors agonists, antagonists and modulators (e.g. tamoxifen, 4-OHT, fulvestrant, DPN, PPT), our prices are around 25-50% less than other suppliers.
View products: Aryl hydrocarbon receptor | Estrogen and related | Liver X and farnesoid X receptors (LXR/FXR) | Glucocorticoid Mineralocorticoid | Other | PPAR | Progesterone
- Description:
Synthetic estrogen receptor ligand. Widely used in genome engineering (e.g. CreER/ CRISPR-Cas9).
Purity:>98%
- Description:
Estrogen receptor ligand. For inducible genome manipulation (e.g. Cre-LoxP (CreER)/ TRAP/ CRISPR-Cas9).
Purity:>98%
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ICI 182,780 (Fulvestrant) (HB2501)
Description:Estrogen receptor (ER) antagonist and high affinity GPER agonist
Purity:>99%
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Mifepristone (HB2783)
Description:Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.
Purity:>99%
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Muristerone A (HB3985)
Description:Ecdysone receptor (EcR) agonist. Apoptosis inducer.
Purity:>95%
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Pifithrin-α hydrobromide (HB2478)
Description:p53 inhibitor and Aryl hydrocarbon receptor agonist. Supresses ESC self renewal.
Purity:>98%
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Pioglitazone hydrochloride (HB2554)
Description:Selective PPARγ agonist. Enhances mESCs proliferation and survival.
Purity:>99%
