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PHTPP

(HB2503)
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Product overview

Name PHTPP
Purity >99%
Description Selective ERβ estrogen receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2)
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Biological Data

Biological description Selective ERβ estrogen receptor antagonist. Shows 36-fold selectivity for ERβ over ERα. Active in vivo.

Solubility & Handling

Solubility overview

Soluble in DMSO (33 mM), and in ethanol (100 mM)

Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
Molecular Weight 423.31
Chemical structure PHTPP Chemical Structure
Molecular Formula C20H11F6N3O
CAS Number 805239-56-9
PubChem identifier 11201035
SMILES OC1=CC=C(C=C1)C1=C2N=C(C=C(N2N=C1C1=CC=CC=C1)C(F)(F)F)C(F)(F)F
InChi InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H
InChiKey AEZPAUSGTAHLOQ-UHFFFAOYSA-N
MDL number MFCD09971112

References for PHTPP

References are publications that support the biological activity of the product

  • Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.

    Weiser MJ et al (2009) Endocrinology 150(4) : 1817-25.
    Read more (PubMedID: 19074580)

  • Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

    Compton DR et al (2004) J Med Chem 47(24) : 5872-93.
    Read more (PubMedID: 15537344)

2 Item(s)

Grouped product items
Order: HB2503
Pack PriceQty
10mg
$217
50mg
$839
Selective ERβ estrogen receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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