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Biological Data
| Biological description | Selective ERβ estrogen receptor antagonist. Shows 36-fold selectivity for ERβ over ERα. Active in vivo. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (33 mM), and in ethanol (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol |
| Chemical structure |  |
| Molecular Formula | C20H11F6N3O |
| PubChem identifier | 11201035 |
| SMILES | OC1=CC=C(C=C1)C1=C2N=C(C=C(N2N=C1C1=CC=CC=C1)C(F)(F)F)C(F)(F)F |
| InChi | InChI=1S/C20H11F6N3O/c21-19(22,23)14-10-15(20(24,25)26)29-18(27-14)16(11-6-8-13(30)9-7-11)17(28-29)12-4-2-1-3-5-12/h1-10,30H |
| InChiKey | AEZPAUSGTAHLOQ-UHFFFAOYSA-N |
References for PHTPP
References are publications that support the biological activity of the product
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Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.
Weiser MJ et al (2009) Endocrinology 150(4) : 1817-25. -
Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.
Compton DR et al (2004) J Med Chem 47(24) : 5872-93.
Selective ERβ estrogen receptor antagonist
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