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Biological Data

Biological description Selective ERβ estrogen receptor antagonist. Shows 36-fold selectivity for ERβ over ERα. Active in vivo.

Solubility & Handling

Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
Molecular Weight 423.31
Chemical structure PHTPP Chemical Structure
Molecular Formula C20H11F6N3O
CAS Number 805239-56-9
PubChem identifier 11201035
SMILES OC1=CC=C(C=C1)C1=C2N=C(C=C(N2N=C1C1=CC=CC=C1)C(F)(F)F)C(F)(F)F
InChiKey AEZPAUSGTAHLOQ-UHFFFAOYSA-N

References for PHTPP

References are publications that support the biological activity of the product
  • Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.

    Weiser MJ et al (2009) Endocrinology 150(4) : 1817-25.
  • Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

    Compton DR et al (2004) J Med Chem 47(24) : 5872-93.