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DPN

(HB2489)
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Product overview

Name DPN
Alternative names Diarylpropionitrile
Purity >98%
Description Selective ERβ estrogen receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Selective ERβ estrogen receptor agonist (Kd values are 5 and 400 nM at ERβ and ERα respectively). Shows 70-fold selectivity at ERβ over ERα. Shows neuroprotective effects. Active in vivo.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100 mM) and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2,3-bis(4-Hydroxyphenyl)-propionitrile
Molecular Weight 239.27
Chemical structure DPN [1428-67-7] Chemical Structure
Molecular Formula C15H13NO2
CAS Number 1428-67-7
PubChem identifier 102614
SMILES C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
InChi InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
InChiKey GHZHWDWADLAOIQ-UHFFFAOYSA-N
MDL number MFCD01695412

References for DPN

References are publications that support the biological activity of the product

  • Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

    Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.
    Read more (PubMedID: 22981216)

  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.
    Read more (PubMedID: 21420980)

  • Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.

    Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.
    Read more (PubMedID: 15126114)

  • Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.

    Meyers MJ et al (2001) J Med Chem 44(24) : 4230-51.
    Read more (PubMedID: 11708925)

4 Item(s)

Grouped product items
Order: HB2489
Pack PriceQty
10mg
$84
50mg
$364
Selective ERβ estrogen receptor agonist
Shipping Info

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Hazardous: $35

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