Selective ERα estrogen receptor antagonist (Ki values are 2.7 and 1800 nM at ERα and ERβ respectively). Shows >200-fold selectivity for Erα compared to Erβ. Active in vivo.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM)
Storage instructions
+4°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus.
Davis AM et al (2006) Mol Reprod Dev 73(8) : 1034-44.