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MPP dihydrochloride

(HB2502)
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Product overview

Name MPP dihydrochloride
Alternative names Methyl-Piperidinopyrazole
Purity >98%
Description Selective ERα estrogen receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Selective ERα estrogen receptor antagonist (Ki values are 2.7 and 1800 nM at ERα and ERβ respectively). Shows >200-fold selectivity for Erα compared to Erβ. Active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1,3-Bis(4-hydroxyphenyl)-4-methyl-5 -[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
Molecular Weight 542.5
Chemical structure MPP dihydrochloride Chemical Structure
Molecular Formula C29H31N3O3.2HCl
CAS Number 911295-24-4
PubChem identifier 45073474
SMILES OC(C=C4)=CC=C4N1C(C(C=C3)=CC=C3OCCN2CCCCC2)=C(C)C(C5=CC=C(O)C=C5)=N1.Cl.Cl
InChi InChI=1S/C29H31N3O3/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31/h5-16,33-34H,2-4,17-20H2,1H3
InChiKey SMPRQALBFACGGO-UHFFFAOYSA-N
MDL number MFCD06411603

References for MPP dihydrochloride

References are publications that support the biological activity of the product

  • Effect of a putative ERalpha antagonist, MPP, on food intake in cycling and ovariectomized rats.

    Santollo J et al (2009) Physiol Behav 97(2) : 193-8.
    Read more (PubMedID: 19254732)

  • The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus.

    Davis AM et al (2006) Mol Reprod Dev 73(8) : 1034-44.
    Read more (PubMedID: 16688783)

  • Antagonists selective for estrogen receptor alpha.

    Sun J et al (2002) Endocrinology 143(3) : 941-7.
    Read more (PubMedID: 11861516)

3 Item(s)

Grouped product items
Order: HB2502
Pack PriceQty
5mg
$90
10mg
$169
50mg
$702
Selective ERα estrogen receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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