Product overview

Name PPT
Purity >98%
Description Selective ERα estrogen receptor agonist
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Biological Data

Biological description Selective ERα estrogen receptor agonist (Kd values are 2 and 1000 nM at ERα and ERβ respectively). Displays a 410-fold higher selectivity for ERα over ERβ. Shows neuroprotective effects. Active in vivo.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
Molecular Weight 386.45
Chemical structure PPT [263717-53-9] Chemical Structure
Molecular Formula C24H22N2O3
CAS Number 263717-53-9
PubChem identifier 6095481
SMILES CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
InChi InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
InChiKey UOSWGERPQQOSHS-UHFFFAOYSA-N
MDL number MFCD03453628

References for PPT

References are publications that support the biological activity of the product
  • Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

    Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.
  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.
  • Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.

    Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.

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