Product overview

Name PPT
Purity >98%
Description Selective ERα estrogen receptor agonist
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Biological Data

Biological description Selective ERα estrogen receptor agonist (Kd values are 2 and 1000 nM at ERα and ERβ respectively). Displays a 410-fold higher selectivity for ERα over ERβ. Shows neuroprotective effects. Active in vivo.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
Molecular Weight 386.45
Chemical structure PPT [263717-53-9] Chemical Structure
Molecular Formula C24H22N2O3
CAS Number 263717-53-9
PubChem identifier 6095481
InChi InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
MDL number MFCD03453628

References for PPT

References are publications that support the biological activity of the product
  • Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

    Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.
  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.
  • Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.

    Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.

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