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Mifepristone

(HB2783)
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Product overview

Name Mifepristone
Alternative names RU486 | RU38486
Purity >99%
Description Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (5) Frequently bought together
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Biological Data

Biological description

Potent glucocorticoid (GR) and progesterone receptor (PR) antagonist (EC50 values are 2, 10.6 and 9.5 nM at GR, PR-A and PR-B respectively). Also weakly binds the androgen receptor. Shows higher affinity for PRs than progesterone. Shows neuroprotective and antitumor effects. Active in vivo. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.

Solubility & Handling

Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
Molecular Weight 429.6
Chemical structure Mifepristone Chemical Structure
Molecular Formula C29H35NO2
CAS Number 84371-65-3
PubChem identifier 55245
SMILES [H][C@@]23CCC1=CC(CCC1=C2[C@@H]([C@]5=CC=C(N(C)C)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@](C#CC)4O)=O
InChiKey VKHAHZOOUSRJNA-GCNJZUOMSA-N

References for Mifepristone

References are publications that support the biological activity of the product

  • Tamoxifen- And Mifepristone-Inducible Versions of CRISPR Effectors, Cas9 and Cpf1

    Dominguez-Monedero et al (2018) ACS Synth Biol. 7(9) : 2160-2169
    Read more (PubMedID: 30138555)

  • The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature.

    Yuan H et al (2012) Cancer Prev Res (Phila) 5(5) : 754-64.
    Read more (PubMedID: 22427346)

  • Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice.

    Llorens-Martã?n M et al (2011) PLoS One 6(11) : e28376.
    Read more (PubMedID: 22140582)

  • Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons.

    Rakotomamonjy J et al (2011) FASEB J 25(11) : 3999-4010.
    Read more (PubMedID: 21795502)

  • Binding of the anti-progestin RU-486 to rat ovary steroid receptors.

    Schreiber JR et al (1983) Contraception 28(1) : 77-85.
    Read more (PubMedID: 6627946)

5 Item(s)

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Order: HB2783
Pack PriceQty
100mg
$85
Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.
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