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Mifepristone

(HB2783)
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Product overview

Name Mifepristone
Alternative names RU486 | RU38486
Purity >99%
Description Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (5) Frequently bought together
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Biological Data

Biological description

Potent glucocorticoid (GR) and progesterone receptor (PR) antagonist (EC50 values are 2, 10.6 and 9.5 nM at GR, PR-A and PR-B respectively). Also weakly binds the androgen receptor. Shows higher affinity for PRs than progesterone. Shows neuroprotective and antitumor effects. Active in vivo. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.

Solubility & Handling

Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
Molecular Weight 429.6
Chemical structure Mifepristone Chemical Structure
Molecular Formula C29H35NO2
CAS Number 84371-65-3
PubChem identifier 55245
SMILES [H][C@@]23CCC1=CC(CCC1=C2[C@@H]([C@]5=CC=C(N(C)C)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@](C#CC)4O)=O
InChiKey VKHAHZOOUSRJNA-GCNJZUOMSA-N

References for Mifepristone

References are publications that support the biological activity of the product

  • Tamoxifen- And Mifepristone-Inducible Versions of CRISPR Effectors, Cas9 and Cpf1

    Dominguez-Monedero et al (2018) ACS Synth Biol. 7(9) : 2160-2169
    Read more (PubMedID: 30138555)

  • The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature.

    Yuan H et al (2012) Cancer Prev Res (Phila) 5(5) : 754-64.
    Read more (PubMedID: 22427346)

  • Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice.

    Llorens-Martã?n M et al (2011) PLoS One 6(11) : e28376.
    Read more (PubMedID: 22140582)

  • Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons.

    Rakotomamonjy J et al (2011) FASEB J 25(11) : 3999-4010.
    Read more (PubMedID: 21795502)

  • Binding of the anti-progestin RU-486 to rat ovary steroid receptors.

    Schreiber JR et al (1983) Contraception 28(1) : 77-85.
    Read more (PubMedID: 6627946)

5 Item(s)

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Order: HB2783
Pack PriceQty
100mg
$86
Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.
Shipping Info

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Hazardous: $35

Shipped on ice: $35

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