Potent glucocorticoid (GR) and progesterone receptor (PR) antagonist (EC50 values are 2, 10.6 and 9.5 nM at GR, PR-A and PR-B respectively). Also weakly binds the androgen receptor. Shows higher affinity for PRs than progesterone. Shows neuroprotective and antitumor effects. Active in vivo. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.
Solubility & Handling
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.