Product overview

Name Tamoxifen
Alternative names TAM
Purity >99%

Estrogen receptor antagonist/ partial agonist. May be used in genome engineering (e.g. CreER/ CRISPR-Cas9).

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Tamoxifen product vial image | Hello Bio

Biological Data

Biological description

Estrogen receptor antagonist and partial agonist. It is also a potent chloride channel HSV-1 inhibitor. It is blood brain barrier permeable.

Tamoxifen inhibits tumor growth and induces apoptosis in breast cancer cells. It also selectively inhibits sterol biosynthesis (IC50 = 1000 nM) and shows neuroprotective potential.

It is used in gene editing in which tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation and lineage tracing studies in mice.

It can also switch on the inducible CRISPR-Cas9 system (iCas).

Solubility & Handling

Storage instructions

Room temperature

Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
Molecular Weight 371.52
Chemical structure Tamoxifen  [10540-29-1] Chemical Structure
Molecular Formula C26H29NO
CAS Number 10540-29-1
PubChem identifier 2733526
InChi InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
MDL number MFCD00010454

References for Tamoxifen

References are publications that support the biological activity of the product
  • A Chemical-Inducible CRISPR-Cas9 System for Rapid Control of Genome Editing

    Liu et al (2016) Nat Chem Biol. 12(11) : 980-987
  • Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.

    Zheng K et al (2014) Biochem Biophys Res Commun 446(4) : 990-6.
  • Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.

    Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73.
  • Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.

    Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8.
  • Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.

    Paul R et al (1998) J Pharmacol Exp Ther 285(3) : 1296-302.

5 Item(s)

These publications cite the use of Tamoxifen purchased from Hello Bio:
  • Sex difference in the vulnerability to hippocampus plasticity impairment after binge-like ethanol exposure in adolescent rat: Is estrogen the key?

    Rabiant K et al (2021) Addict Biol 26(4) : e13002
    PubMedID: 33511744

1 Item