Estrogen receptor antagonist and partial agonist. It is also a potent chloride channel HSV-1 inhibitor. It is blood brain barrier permeable.
Tamoxifen inhibits tumor growth and induces apoptosis in breast cancer cells. It also selectively inhibits sterol biosynthesis (IC50 = 1000 nM) and shows neuroprotective potential.
It is used in gene editing in which tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation and lineage tracing studies in mice.
It can also switch on the inducible CRISPR-Cas9 system (iCas).
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.
Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73.
Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.
Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8.
Antibody to c-Fos - an immediate early gene used as a marker of neuronal activity. Part of the ValidAb™ range of highly validated, data-rich antibodies.
![Tamoxifen [10540-29-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0601_2.png "Tamoxifen [10540-29-1]")
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