Nuclear Receptors

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Nuclear hormone receptors (nuclear receptors) are specialised transcription factors which bind to specific sequences of DNA of particular target genes. They regulate transcription of these target genes in response to a variety of endogenous ligands. Nuclear receptors are classified into two major subfamilies: steroid and non-steroid hormone receptors. Steroid hormone receptors include receptors for estrogen (ER), androgen, glucocorticoid, mineralocorticoid and progesterone. Examples of non-steroid hormone receptors include thyroid receptors, retinoic acid receptors and peroxisome proliferator-activated receptors (PPAR). Researchers can save up to 50% on nuclear hormone receptor agonists, antagonists and modulators from Hello Bio - they are up to half the price of other suppliers.

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  1. Description:

    Synthetic estrogen receptor ligand. Widely used in genome engineering (e.g. CreER/ CRISPR-Cas9).

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $85
    Qty:
    Pack:
    10mg
    Price:
    $150
    Qty:
    Pack:
    25mg
    Price:
    $310
    Qty:
    Pack:
    50mg
    Price:
    $548
    Qty:
  2. Description:

    Estrogen receptor (ER) antagonist and high affinity GPER agonist

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $52
    Qty:
    Pack:
    10mg
    Price:
    $88
    Qty:
    Pack:
    50mg
    Price:
    $205
    Qty:
  3. Mifepristone (HB2783)

    Description:

    Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.

    Purity:

    >99%

    Pack:
    100mg
    Price:
    $70
    Qty:
  4. Muristerone A (HB3985)

    Description:

    Ecdysone receptor (EcR) agonist. Apoptosis inducer.

    Purity:

    >95%

    Pack:
    1mg
    Price:
    $182
    Qty:
  5. PHTPP (HB2503)

    Description:

    Selective ERβ estrogen receptor antagonist

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $174
    Qty:
    Pack:
    50mg
    Price:
    $674
    Qty:
  6. Description:

    p53 inhibitor and Aryl hydrocarbon receptor agonist. Supresses ESC self renewal.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $135
    Qty:
  7. Description:

    Selective PPARγ agonist. Enhances mESCs proliferation and survival.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $44
    Qty:
    Pack:
    50mg
    Price:
    $140
    Qty:
  8. Pioglitazone (HB4139)

    Description:

    Selective PPARγ agonist

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $43
    Qty:
    Pack:
    25mg
    Price:
    $138
    Qty:
  9. Ponasterone A (HB4033)

    Description:

    Ecdysone receptor (EcR) agonist

    Purity:

    >95%

    Pack:
    5mg
    Price:
    $227
    Qty:
    Pack:
    25mg
    Price:
    $900
    Qty:
  10. PPT (HB2499)

    Description:

    Selective ERα estrogen receptor agonist

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $79
    Qty:
    Pack:
    10mg
    Price:
    $155
    Qty:
    Pack:
    25mg
    Price:
    $317
    Qty:

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