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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
VU 0357017 hydrochloride (HB1498)
Description:Potent, selective M1 receptor allosteric agonist
Purity:>98%
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WAY 100635 maleate (HB1790)
Description:Potent 5-HT1A receptor antagonist. D4 receptor agonist.
Purity:>99%
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YM 298198 hydrochloride (HB0664)
Description:Potent, selective, non-competitive mGlu1 antagonist
Purity:>99%
