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Biological Data Biological description Potent 5-HT1A receptor antagonist (IC50 value = 2.2 nM). More than 100-fold selective for 5-HT1A compared with other 5-HT receptors. Also acts as an agonist at D4 receptor (IC50 value = 16 nM). Active in vivo .
Solubility & Handling Storage instructions room temperature (desiccate)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N -[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N -2-pyridinylcyclohexanecarboxamide maleate
Chemical structure
Molecular Formula C25 H34 N4 O2 .C4 H4 O4
PubChem identifier 11957721
SMILES O=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(\C=C/C(O)=O)O
InChiKey XIGAHNVCEFUYOV-BTJKTKAUSA-N
References for WAY 100635 maleate References are publications that support the biological activity of the product
WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. Marona-Lewicka D et al (2009) Behav Pharmacol 20(1) : 114-8. WAY-100635 is a potent dopamine D4 receptor agonist. Chemel BR et al (2006) Psychopharmacology (Berl) 188(2) : 244-51. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Forster EA et al (1995) Eur J Pharmacol 281(1) : 81-8.
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Potent 5-HT1A receptor antagonist. D4 receptor agonist.