VU 29 is a a potent mGlu5 receptor positive allosteric modulator (EC50 = 9 nM). It selectively potentiates mGlu5 over mGlu1 and mGlu2 receptors (EC50 values are 557 nM and 1.51 µM for mGlu1 and mGlu2 receptors respectively). CDPPB analog.
VU 29 potentiates DHPG-induced LTP and TBS-induced LTP in rat hippocampal slices.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Chen Y et al (2007) Mol Pharmacol 71(5) : 1389-98.
Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
de Paulis T et al (2006) J Med Chem 49(11) : 3332-44.
![VU 29 [890764-36-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0642.png "VU 29 [890764-36-0]")
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