VU 29 is a a potent mGlu5 receptor positive allosteric modulator (EC50 = 9 nM). It selectively potentiates mGlu5 over mGlu1 and mGlu2 receptors (EC50 values are 557 nM and 1.51 µM for mGlu1 and mGlu2 receptors respectively). CDPPB analog.
VU 29 potentiates DHPG-induced LTP and TBS-induced LTP in rat hippocampal slices.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Chen Y et al (2007) Mol Pharmacol 71(5) : 1389-98.
Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
de Paulis T et al (2006) J Med Chem 49(11) : 3332-44.
![VU 29 [890764-36-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0642.png "VU 29 [890764-36-0]")
Understanding purity and quality - a guide for life scientists
