Product overview

Name VU 29
Purity >98%
Description Potent mGlu5 positive allosteric modulator
Write Your Own Review
You're reviewing:VU 29
Rate this item:


VU 29 product vial image | Hello Bio

Biological Data

Biological description

VU 29 is a a potent mGlu5 receptor positive allosteric modulator (EC50 = 9 nM). It selectively potentiates mGlu5 over mGlu1 and mGlu2 receptors (EC50 values are 557 nM and 1.51 µM for mGlu1 and mGlu2 receptors respectively). CDPPB analog.

VU 29 potentiates DHPG-induced LTP and TBS-induced LTP in rat hippocampal slices.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Purity >98%
Chemical name N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
Molecular Weight 384.39
Chemical structure VU 29  [890764-36-0] Chemical Structure
Molecular Formula C22H16N4O3
CAS Number 890764-36-0
PubChem identifier 11610682
SMILES C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4
Source Synthetic
InChi InChI=1S/C22H16N4O3/c27-22(17-11-13-19(14-12-17)26(28)29)23-21-15-20(16-7-3-1-4-8-16)24-25(21)18-9-5-2-6-10-18/h1-15H,(H,23,27)
Appearance Yellow solid

References for VU 29

References are publications that support the biological activity of the product
  • mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.

    Ayala JE et al (2009) Neuropsychopharmacology 34(9) : 2057-71.
  • Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

    Chen Y et al (2007) Mol Pharmacol 71(5) : 1389-98.
  • Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.

    de Paulis T et al (2006) J Med Chem 49(11) : 3332-44.

3 Item(s)