mGlu5 receptor negative allosteric modulator (IC50 = 61 nM). Exhibits little or no activity at mGlu1-4 and mGlu7-8 receptors. Blood-brain barrier permeable.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (25mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.
Lindsley CW et al (2011) ACS Chem Neurosci 2(8) : 471-482.
![VU 0360223 [1274859-33-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0637.png "VU 0360223 [1274859-33-4]")
Understanding purity and quality - a guide for life scientists
