mGlu4 receptor positive allosteric modulator (EC50 = 0.29 µM). Displays high affinity for MAO-B over MAO-A (Ki values are 0.72 and 8.5 µM respectively). Exhibits weak PAM activity at mGlu6 receptor and antagonist activity at mGlu5. Blood brain barrier permeable. Reverses forelimb asymmetry and haloperidol-induced catalepsy in rats.
Solubility & Handling
Soluble in DMSO (100mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
Jones CK et al (2012) J Pharmacol Exp Ther 340(2) : 404-21.